Ford, A. H., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., Almeida, O. P.

[Correction Notice: An erratum for this article was reported in Vol 77(8) of Neurology (see record [rid]2011-21984-022[/rid]). In the original article, the daily dose of vitamin B12 used in the trial was reported as 400 μg, but it should have been 500 μg.] Objective: To investigate whether supplementing older men with vitamins B12, B6, and […]

Chan, Amy, Paskavitz, James, Remington, Ruth, Rasmussen, Shelly, Shea, Thomas B.

We examined the efficacy of a vitamin/nutriceutical formulation (folate, vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and acetyl- L-carnitine) in a 12-month, open-label trial with 14 community-dwelling individuals with early-stage Alzheimer’s disease. Participants improved in the Dementia Rating Scale and Clock-drawing tests (Clox 1 and 2). Family caregivers reported improvement in multiple domains of the […]

Jyvakorpi, Satu K., Puranen, Taija, Pitkälä, Kaisu H., Suominen, Merja H.

Background: Nutritional status often deteriorates in Alzheimer’s disease (AD). Less is known about whether nutritional care reverses malnutrition and its harmful consequences in AD. The aim of this study is to examine whether individualized nutritional care has an effect on weight, nutrition, health, physical functioning, and quality of life in older individuals with AD and […]

Llewellyn, David J., Lang, Iain A., Langa, Kenneth M., Muniz-Terrera, Graciela, Phillips, Caroline L., Cherubini, Antonio, Ferrucci, Luigi, Melzer, David

Background: To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia.; Methods: We determined whether low levels of serum 25-hydroxyvitamin D (25[OH]D) were associated with an increased risk of substantial cognitive decline in the InCHIANTI population-based study conducted in Italy between 1998 and 2006 with follow-up assessments […]

Remington, Ruth, Chan, Amy, Paskavitz, James, Shea, Thomas B.

Recent studies demonstrated efficacy of a vitamin/ nutriceutical formulation (folate, vitamin B12, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and acetyl-L-carnitine) for mild to moderate Alzheimer’s disease. Herein, we tested the efficacy of this formulation in a small cohort of 12 institutionalized patients diagnosed with moderate-stage to later-stage Alzheimer’s disease. Participants were randomly separated into treatment of […]

Ford, A. H., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., Almeida, O. P.

Objective: To investigate whether supplementing older men with vitamins B(12), B(6), and folic acid improves cognitive function.; Methods: The investigators recruited 299 community-representative hypertensive men 75 years and older to a randomized, double-blind controlled clinical trial of folic acid, vitamin B(6), and B(12) supplementation vs placebo over 2 years. The primary outcome of interest was […]

Stein, Mark S., Scherer, Samuel C., Ladd, Kylie S., Harrison, Leonard C.

Poor vitamin D nutrition is linked with dementia, but vitamin D has not been tested in a randomized controlled trial (RCT) in Alzheimer’s disease (AD). Nasal insulin acutely improves cognition and vitamin D upregulates insulin receptor expression and enhances insulin action. In an RCT we examined the effect of high-dose vitamin D followed by nasal […]

de Waal, Hanneke, Stam, Cornelis J., Lansbergen, Marieke M., Wieggers, Rico L., Kamphuis, Patrick J. G. H., Scheltens, Philip, Maestú, Fernando, van Straaten, Elisabeth C. W.

Background: Synaptic loss is a major hallmark of Alzheimer’s disease (AD). Disturbed organisation of large-scale functional brain networks in AD might reflect synaptic loss and disrupted neuronal communication. The medical food Souvenaid, containing the specific nutrient combination Fortasyn Connect, is designed to enhance synapse formation and function and has been shown to improve memory performance […]

Annweiler, C., Rolland, Y., Schott, A.M., Blain, H., Vellas, B., Beauchet, O.

Background: Hypovitaminosis D has been cross-sectionally associated with dementia and stroke. The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women.; Methods: Forty high-functioning older women (78.4 years, 76.4/82.0; median, 25th/75th percentile) from the EPIDOS […]