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Efficacy of a vitamin/nutriceutical formulation for moderate-stage to later-stage Alzheimer’s disease: a placebo-controlled pilot study


Remington, Ruth, Chan, Amy, Paskavitz, James, Shea, Thomas B.


American Journal Of Alzheimer's Disease And Other Dementias, Volume: 24, No.: 1, Pages.: 27-33

Year of Publication



Recent studies demonstrated efficacy of a vitamin/ nutriceutical formulation (folate, vitamin B12, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and acetyl-L-carnitine) for mild to moderate Alzheimer’s disease. Herein, we tested the efficacy of this formulation in a small cohort of 12 institutionalized patients diagnosed with moderate-stage to later-stage Alzheimer’s disease. Participants were randomly separated into treatment of placebo groups. Participants receiving the formulation demonstrated a clinically significant delay in decline in the Dementia Rating Scale and clock-drawing test as compared to those receiving placebo. Institutional caregivers reported approximately 30% improvement in the Neuropyschiatric Inventory and maintenance of performance in the Alzheimer’s Disease Cooperative Study-Activities of Daily Living for more than 9 months. This formulation holds promise for delaying the decline in cognition, mood, and daily function that accompanies the progression of Alzheimer’s disease, and may be particularly useful as a supplement for pharmacological approaches during later stages of this disorder. A larger trial is warranted.;

Bibtex Citation

@article{Remington_2008, doi = {10.1177/1533317508325094}, url = {}, year = 2008, month = {dec}, publisher = {{SAGE} Publications}, volume = {24}, number = {1}, pages = {27--33}, author = {R. Remington and A. Chan and J. Paskavitz and T. B. Shea}, title = {Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer{textquotesingle}s disease: A Placebo-controlled Pilot Study}, journal = {American Journal of Alzheimer{textquotesingle}s Disease and Other Dementias} }


activities of daily living, affect, aged, aged, 80 and over, alzheimer disease, chemistry pharmaceutical, cognition, cohort studies, diagnosis, dietary supplements, drug effects, drug therapy, drug therapy combination, humans, physiopathology, pilot projects, psychology, severity of illness index, therapeutic use, treatment outcome, vitamins

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes



Nursing Homes

Pharmaceutical Interventions