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Nutritional treatment of aged individuals with Alzheimer disease living at home with their spouses: study protocol for a randomized controlled trial


Jyvakorpi, Satu K., Puranen, Taija, Pitkälä, Kaisu H., Suominen, Merja H.


Trials, Volume: 13, Pages.: 66-66

Year of Publication



Background: Nutritional status often deteriorates in Alzheimer’s disease (AD). Less is known about whether nutritional care reverses malnutrition and its harmful consequences in AD. The aim of this study is to examine whether individualized nutritional care has an effect on weight, nutrition, health, physical functioning, and quality of life in older individuals with AD and their spouses living at home.; Methods: AD patients and their spouses (aged > 65 years) living at home (n = 202, 102 AD patients) were recruited using central AD registers in Finland. The couples were randomized into intervention and control groups. A trained nutritionist visited intervention couples 4-8 times at their homes and the couples received tailored nutritional care. When necessary, the couples were given protein and nutrient-enriched complementary drinks. All intervention couples were advised to take vitamin D 20 μg/day. The intervention lasted for one year. The couples of the control group received a written guide on nutrition of older people. Participants in the intervention group were assessed every three months. The primary outcome measure is weight change. Secondary measures are the intake of energy, protein, and other nutrients, nutritional status, cognition, caregiver’s burden, depression, health related quality of life and grip strength.; Discussion: This study provides data on whether tailored nutritional care is beneficial to home-dwelling AD patients and their spouses.; Trial Registration: ACTRN 12611000018910.;

Bibtex Citation

@article{Jyvakorpi_2012, doi = {10.1186/1745-6215-13-66}, url = {}, year = 2012, month = {may}, publisher = {Springer Nature}, volume = {13}, number = {1}, author = {Satu K Jyvakorpi and Taija Puranen and Kaisu H Pitkala and Merja H Suominen}, title = {Nutritional treatment of aged individuals with Alzheimer disease living at home with their spouses: study protocol for a randomized controlled trial}, journal = {Trials} }


aged, alzheimer disease, body weight, caregivers, cognition, complications, counseling, depression, diagnosis, dietary supplements, etiology, finland, geriatric assessment, grip, hand strength, humans, independent living, malnutrition, nutrition, nutrition assessment, nutrition therapy, nutritional status, nutritionist, physiopathology, prevention & control, psychology, quality of life, research design, spouses, strength, supplements, therapeutic use, therapy, time factors, treatment outcome, visits, vitamin d, vitamins, weight

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes

Carer Burden (instruments measuring burden), Cognition, Depression and Anxiety, Other, Physical Health, Quality of Life of Person With Dementia


Extra Care Housing

Type of Interventions

Non-pharmacological Treatment, Pharmaceutical Interventions

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements

Non-Pharmaceutical Interventions