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Vitamins B(12), B(6), and folic acid for cognition in older men


Ford, A. H., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., Almeida, O. P.


Neurology, Volume: 75, No.: 17, Pages.: 1540-1547

Year of Publication



Objective: To investigate whether supplementing older men with vitamins B(12), B(6), and folic acid improves cognitive function.; Methods: The investigators recruited 299 community-representative hypertensive men 75 years and older to a randomized, double-blind controlled clinical trial of folic acid, vitamin B(6), and B(12) supplementation vs placebo over 2 years. The primary outcome of interest was the change in the cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-cog). A secondary aim of the study was to determine if supplementation with vitamins decreased the risk of cognitive impairment and dementia over 8 years.; Results: The groups were well-balanced for demographic and biochemical parameters. There was no difference in the ADAS-cog change from baseline to 24 months between the placebo (0.8, SD 4.0) and vitamins group (0.7, SD 3.4). The adjusted scores in the treatment groups did not differ over time (placebo 0.2 lower, z = 0.71, p = 0.478). There was a nonsignificant 28% decrease in the risk of cognitive impairment (odds ratio 0.72, 95% confidence interval 0.25-2.09) and dementia (hazard ratio 0.72, 95% confidence interval 0.29-1.78) over 8 years of follow-up.; Conclusions: The daily supplementation of vitamins B(12), B(6), and folic acid does not benefit cognitive function in older men, nor does it reduce the risk of cognitive impairment or dementia.; Classification Of Evidence: This study provides Class I evidence that vitamin supplementation with daily doses of 500 μg [DOSAGE ERROR CORRECTED] of B(12), 2 mg of folic acid, and 25 mg of B(6) over 2 years does not improve cognitive function in hypertensive men aged 75 and older.;

Bibtex Citation

@article{Ford_2010, doi = {10.1212/wnl.0b013e3181f962c4}, url = {}, year = 2010, month = {sep}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, volume = {75}, number = {17}, pages = {1540--1547}, author = {A. H. Ford and L. Flicker and H. Alfonso and J. Thomas and R. Clarnette and R. Martins and O. P. Almeida}, title = {Vitamins B12, B6, and folic acid for cognition in older men}, journal = {Neurology} }


acid, administration & dosage, aged, aged, 80 and over, and, blood, cognition, cognition disorders, community health planning, dementia, dietary supplements, double-blind method, drug effects, folic, folic acid, geriatrics, homocysteine, humans, hypertensive, male, men, neuropsychological tests, older, patient compliance, prevention & control, statistics & numerical data, time factors, vitamin b 12, vitamin b 6, vitamin b complex, vitamins

Countries of Study


Types of Dementia

Dementia (general / unspecified), Mild Cognitive Impairment (MCI)

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions, Risk Factor Modification

Risk Factor Modifications

At risk population

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements