This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer’s disease: A 1-year, open-label pilot study with an 16-month caregiver extension


Chan, Amy, Paskavitz, James, Remington, Ruth, Rasmussen, Shelly, Shea, Thomas B.


American Journal of Alzheimer's Disease and Other Dementias, Volume: 23, No.: 6, Pages.: 571-585

Year of Publication



We examined the efficacy of a vitamin/nutriceutical formulation (folate, vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and acetyl- L-carnitine) in a 12-month, open-label trial with 14 community-dwelling individuals with early-stage Alzheimer’s disease. Participants improved in the Dementia Rating Scale and Clock-drawing tests (Clox 1 and 2). Family caregivers reported improvement in multiple domains of the Neuropsychiatric Inventory (NPI) and maintenance of performance in the Alzheimer’s Disease Cooperative Study–Activities of Daily Living (ADL). Sustained performance was reported by caregivers for those participants who continued in an 16-month extension. Performance on the NPI was equivalent to published findings at 3 to 6 months for donepezil and exceeded that of galantamine and their historical placebos. Participants demonstrated superior performance for more than 12 months in NPI and ADL versus those receiving naproxen and rofecoxib or their placebo group. This formulation holds promise for treatment of early-stage Alzheimer’s disease prior to and/or as a supplement for pharmacological approaches. A larger, placebo-controlled trial is warranted. (PsycINFO Database Record (c) 2014 APA, all rights reserved). (journal abstract)

Bibtex Citation

@article{Chan_2008, doi = {10.1177/1533317508325093}, url = {}, year = 2008, month = {nov}, publisher = {{SAGE} Publications}, volume = {23}, number = {6}, pages = {571--585}, author = {A. Chan and J. Paskavitz and R. Remington and S. Rasmussen and T. B. Shea}, title = {Efficacy of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer{textquotesingle}s Disease: A 1-year, Open-label Pilot Study With an 16-Month Caregiver Extension}, journal = {American Journal of Alzheimer{textquotesingle}s Disease and Other Dementias} }


acetyl, alzheimer’s disease, b6, caregiver extension, caregivers, community involvement, communitydwelling individuals, cysteine, folate, lcarnitine, methionine, nutriceutical formulation, pharmacology, treatment effectiveness evaluation, treatment efficacy, vitamins

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Before and After Study

Type of Outcomes

ADLs/IADLs, Behaviour, Cognition



Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements