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This database contains 10 studies, archived under the term: "adolescent"

Alzheimer’s disease: is pacemaker implantation safe?

Aim: To evaluate the safety of pacemaker implantation in patients with Alzheimer’s disease (AD).; Methods: We reviewed all cases admitted to our institution between January 2008 and June 2009, with symptomatic bradyarrhythmia for whom a permanent pacemaker was implanted. Beginning in June 2009, we prospectively collected data from all patients with the same diagnosis and […]

DHEA and cognition in HIV-positive patients with non-major depression

Background: Dihydroepiandrosterone (DHEA) has been investigated for its potential role in improving cognition in a number of patient populations. Treatment options are limited for HIV-associated neurocognitive disorders.; Objective: The authors tested the effect of DHEA administration on the cognitive functioning of HIV-positive subjects with non-major depression.; Method: The neuropsychological testing data for 60 HIV-positive patients […]

A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects

Background and Objectives: Avagacestat is an orally active γ-secretase inhibitor that selectively inhibits amyloid β (Aβ) synthesis in cell culture and animal models. The objective of the current study was to assess the pharmacokinetics, pharmacodynamics, safety and tolerability of multiple doses of avagacestat over 28 days in healthy young men and elderly men and women […]

Dairy consumption and working memory performance in overweight and obese adults

All individuals will experience some degree of cognitive impairment in their later years. Diet is one readily modifiable factor that may influence cognitive function and psychological well-being. Very little research has considered the potential role of dairy foods in modulating cognitive and psychological functions. The objective of this study was to determine the effect of […]

The synergistic effect of acupuncture and computer-based cognitive training on post-stroke cognitive dysfunction: a study protocol for a randomized controlled trial of 2 × 2 factorial design

Background: Stroke is one of the most common causes of cognitive impairment. Up to 75% of stroke survivors may be considered to have cognitive impairment, which severely limit individual autonomy for successful reintegration into family, work and social life. The clinical efficacy of acupuncture with Baihui (DU20) and Shenting (DU24) in stroke and post-stroke cognitive […]

A simple cognitive test which detects early decline in cognitive function

Aim: The aim of this study was to examine our new cognitive test which detects early decline in cognitive function.; Methods: Our newly developed Simple Cognitive test (SC-test) takes 3 minutes, during which participants choose the figures in which both the shape and color are different from the figure on the left end of each […]

Physical activity over the life course and its association with cognitive performance and impairment in old age

Objective: To determine how physical activity at various ages over the life course is associated with cognitive impairment in late life.; Design: Cross-sectional study.; Setting: Four U.S. sites.; Participants: Nine thousand three hundred forty-four women aged 65 and older (mean 71.6) who self-reported teenage, age 30, age 50, and late-life physical activity.; Measurements: Logistic regression […]

Learning opportunities in a residential aged care facility: the role of supported placements for first-year nursing students

The residential aged care sector is reportedly a less attractive career choice for nursing students than other sectors. Research shows that students are often fearful of working with residents with dementia when they are inadequately supported on clinical placements by aged care staff. Thirty first-year nursing students attended a 2-week placement in one of two […]

Comparison of two analytical platforms for the clinical qualification of Alzheimer’s disease biomarkers in pathologically-confirmed dementia

Combined analysis of the Alzheimer’s disease (AD) biomarkers amyloid-β(1-42) (Aβ(1-42)), total tau (T-tau), and hyperphosphorylated tau (P-tau(181P)) in cerebrospinal fluid (CSF) reduces the uncertainty associated with clinical dementia diagnosis. The present study evaluated the diagnostic accuracy of the CSF biomarker concentrations obtained with a multi-analyte Luminex assay (INNO-BIA AlzBio3) in comparison to single-analyte ELISA tests […]

Intergenerational volunteering and quality of life: mixed methods evaluation of a randomized control trial involving persons with mild to moderate dementia

Purpose: This article reports on a mixed methods evaluation of a randomized control trial in Cleveland, Ohio, USA, that assessed whether an intergenerational volunteering intervention could enhance quality of life (QOL) for persons with mild to moderate dementia.; Methods: Fifteen participants were randomized into intervention and control groups. The intervention group participated in hour-long volunteer […]

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