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DHEA and cognition in HIV-positive patients with non-major depression


Bradley, Mark, McElhiney, Martin, Rabkin, Judith


Psychosomatics, Volume: 53, No.: 3, Pages.: 244-249

Year of Publication



Background: Dihydroepiandrosterone (DHEA) has been investigated for its potential role in improving cognition in a number of patient populations. Treatment options are limited for HIV-associated neurocognitive disorders.; Objective: The authors tested the effect of DHEA administration on the cognitive functioning of HIV-positive subjects with non-major depression.; Method: The neuropsychological testing data for 60 HIV-positive patients enrolled in a clinical trial for non-major depression were analyzed to determine if DHEA-treated patients demonstrated improved cognitive functioning versus placebo.; Results: At baseline, 80% of the sample met criteria for asymptomatic cognitive impairment. No benefit in cognitive performance was found on 16 of 17 neuropsychological measures evaluated. One measure showed a modest benefit for placebo-treated patients over DHEA.; Conclusion: DHEA treatment was not associated with improved cognitive performance in HIV-positive patients with non-major depression.; Published by Elsevier Inc.

Bibtex Citation

@article{Bradley_2012, doi = {10.1016/j.psym.2011.08.005}, url = {}, year = 2012, month = {may}, publisher = {Elsevier {BV}}, volume = {53}, number = {3}, pages = {244--249}, author = {Mark Bradley and Martin McElhiney and Judith Rabkin}, title = {{DHEA} and Cognition in {HIV}-Positive Patients with Non-Major Depression}, journal = {Psychosomatics} }


adjuvants immunologic, adolescent, adult, aged, blood, cognition, cognition disorders, complications, dehydroepiandrosterone, depressive disorder, dihydroepiandrosterone, drug effects, drug therapy, female, hiv, hiv infections, humans, interview psychological, male, middle aged, neuropsychological tests, pharmacology, placebos, psychiatric status rating scales, related, statistics & numerical data, therapeutic use, treatment outcome, young adult

Countries of Study


Types of Study

Non randomised controlled trial

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions