This database contains 291 studies, archived under the term: "Behaviour"
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Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial
Cummings, J. L.,
Lyketsos, C. G.,
Peskind, E. R.,
Porsteinsson, A. P.,
Mintzer, J. E.,
Scharre, D. W.,
De La Gandara, J. E.,
Agronin, M.,
Davis, C. S.,
Nguyen, U.,
Shin, P.,
Tariot, P. N.,
Siffert, J.
IMPORTANCE: Agitation is common among patients with Alzheimer disease; safe, effective treatments are lacking. OBJECTIVE: To assess the efficacy, safety, and tolerability of dextromethorphan hydrobromide-quinidine sulfate for Alzheimer disease-related agitation. DESIGN, SETTING, AND PARTICIPANTS: Phase 2 randomized, multicenter, double-blind, placebo-controlled trial using a sequential parallel comparison design with 2 consecutive 5-week treatment stages conducted August […]
Managing agitated behaviour in people with Alzheimer’s disease: The role of live music
Background: Agitation due to Alzheimer’s disease (AD) presents a challenge to occupational therapists working in the older people care sector. Recently background music and music therapy have emerged as promising tools in the management of agitation in AD. This exploratory study investigated whether live music could reduce agitated behaviour in people with AD. Method: A […]
Memantine in moderately-severe-to-severe Alzheimer’s disease: A postmarketing surveillance study
Clerici, Francesca,
Vanacore, Nicola,
Elia, Antonietta,
Spila-Alegiani, Stefania,
Pomati, Simone,
Da Cas, Roberto,
Raschetti, Roberto,
Mariani, Claudio
Background: Postmarketing surveillance studies (PMS) are an important tool for evaluating a drug’s effectiveness and safety in clinical practice. To our knowledge, no PMS on memantine monotherapy for moderately-severe-to-severe Alzheimer’s disease (AD) according to National Institute of Neurological and Communicative Disorders and Stroke—Alzheimer’s Disease and Related Disorders Association criteria has been conducted to date. Objective: […]
Translating the REACH caregiver intervention for use by area agency on aging personnel: The REACH OUT Program
Burgio, Louis D.,
Collins, Irene B.,
Schmid, Bettina,
Wharton, Tracy,
McCallum, Debra,
DeCoster, Jamie
Purpose: The aim of this study was to translate the evidence-based Resources for Enhancing Alzheimer’s Caregiver Health (REACH) II intervention for use in 4 Area Agencies on Aging (AAAs). A secondary aim was to examine possible moderators of treatment outcome. Design and Methods: We used a quasi-experimental pre-post treatment design with no control group. A […]
Impact of ambient bright light on agitation in dementia
Barrick, Ann Louise,
Sloane, Philip D.,
Williams, Christianna S.,
Mitchell, C. Madeline,
Connell, Bettye Rose,
Wood, Wendy,
Hickman, Susan E.,
Preisser, John S.,
Zimmerman, Sheryl
Objective: To evaluate the effect of ambient bright light therapy (BLT) on agitation among institutionalized persons with dementia. Methods: High intensity, low glare ambient lighting was installed in activity and dining areas of a state psychiatric hospital unit in North Carolina and a dementia-specific residential care facility in Oregon. The study employed a cluster-unit crossover […]