This database contains 384 studies, archived under the term: "Other"
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Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial
Importance: Early identification of Alzheimer disease (AD) is important for clinical management and affords the opportunity to assess potential disease-modifying agents in clinical trials. To our knowledge, this is the first report of a randomized trial to prospectively enrich a study population with prodromal AD (PDAD) defined by cerebrospinal fluid (CSF) biomarker criteria and mild […]
No effect of donepezil on striatal dopamine release in mild to moderate Alzheimer’s disease
Objective: Work in experimental animals suggests that an interaction with dopaminergic networks might explain some of the therapeutic effects of the cholinesterase inhibitor class of drugs. This study aimed to test whether acute (single 5 mg) or 4–8 weeks (5–10 mg) of treatment with oral donepezil would elicit measurable striatal dopamine (DA) release in patients […]
Improving decision‐making for feeding options in advanced dementia: A randomized, controlled trial
Objectives: To test whether a decision aid improves quality of decision‐making about feeding options in advanced dementia. Design: Cluster randomized controlled trial. Setting: Twenty‐four nursing homes in North Carolina. Participants: Residents with advanced dementia and feeding problems and their surrogates. Intervention: Intervention surrogates received an audio or print decision aid on feeding options in advanced […]
Ginkgo biloba prevention trials: More than an ounce of prevention learned
Objective: To determine effectiveness of G biloba vs placebo in reducing the incidence of all-cause dementia and Alzheimer disease (AD) in elderly individuals with normal cognition and those with mild cognitive impairment (MCI). Design, Setting, and Participants: Randomized, double-blind, placebo-controlled clinical trial conducted in 5 academic medical centers in the United States between 2000 and […]