This database contains 52 studies, archived under the term: "research design"
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Cognitive behavioural therapy (CBT) for anxiety in people with dementia: study protocol for a randomised controlled trial
Spector, Aimee,
Orrell, Martin,
Lattimer, Miles,
Hoe, Juanita,
King, Michael,
Harwood, Kate,
Qazi, Afifa,
Charlesworth, Georgina
Background: Many people with dementia experience anxiety, which can lead to decreased independence, relationship difficulties and increased admittance to care homes. Anxiety is often treated with antipsychotic medication, which has limited efficacy and serious side effects. Cognitive behavioural therapy (CBT) is widely used to treat anxiety in a range of populations, yet no RCTs on […]
Diagnostic and economic evaluation of new biomarkers for Alzheimer’s disease: the research protocol of a prospective cohort study
Handels, Ron L.H.,
Aalten, Pauline,
Wolfs, Claire A.G.,
OldeRikkert, Marcel,
Scheltens, Philip,
Visser, Pieter Jelle,
Joore, Manuela A.,
Severens, Johan L.,
Verhey, Frans R.J.
Background: New research criteria for the diagnosis of Alzheimer’s disease (AD) have recently been developed to enable an early diagnosis of AD pathophysiology by relying on emerging biomarkers. To enable efficient allocation of health care resources, evidence is needed to support decision makers on the adoption of emerging biomarkers in clinical practice. The research goals […]
The antipsychotic discontinuation in Alzheimer disease trial: clinical rationale and study design
Devanand, D. P.,
Mintzer, Jacobo,
Schultz, Susan,
Sultzer, David,
de la Pena, Danilo,
Gupta, Sanjay,
Colon, Sylvia,
Schimming, Corbett,
Pelton, Gregory H.,
Andrews, Howard,
Levin, Bruce
Objectives: : Research studies on the effects of discontinuing antipsychotic medications in patients with dementia have not identified specific target symptoms or response to antipsychotics prior to discontinuation. The Antipsychotic Discontinuation in Alzheimer Disease (ADAD) trial addresses these issues in a randomized, double-blind, placebo-controlled, multicenter risperidone treatment and discontinuation trial. In Phase A, AD patients […]
Alzheimer’s disease multiple intervention trial (ADMIT): study protocol for a randomized controlled clinical trial
Callahan, Christopher M.,
Boustani, Malaz A.,
Schmid, Arlene A.,
Austrom, Mary G.,
Miller, Douglas K.,
Gao, Sujuan,
Morris, Carrie S.,
Vogel, Mickey,
Hendrie, Hugh C.
Background: Given the current lack of disease-modifying therapies, it is important to explore new models of longitudinal care for older adults with dementia that focus on improving quality of life and delaying functional decline. In a previous clinical trial, we demonstrated that collaborative care for Alzheimer’s disease reduces patients’ neuropsychiatric symptoms as well as caregiver […]
A benefit-finding intervention for family caregivers of persons with Alzheimer disease: study protocol of a randomized controlled trial
Cheng, Sheung-Tak,
Lau, Rosanna W. L.,
Mak, Emily P. M.,
Ng, Natalie S. S.,
Lam, Linda C. W.,
Fung, Helene H.,
Lai, Julian C. L.,
Kwok, Timothy,
Lee, Diana T. F.
Background: Caregivers of relatives with Alzheimer’s disease are highly stressed and at risk for physical and psychiatric conditions. Interventions are usually focused on providing caregivers with knowledge of dementia, skills, and/or support, to help them cope with the stress. This model, though true to a certain extent, ignores how caregiver stress is construed in the […]
Medication adherence and tolerability of Alzheimer’s disease medications: study protocol for a randomized controlled trial
Campbell, Noll L.,
Dexter, Paul,
Perkins, Anthony J.,
Gao, Sujuan,
Li, Lang,
Skaar, Todd C.,
Frame, Amie,
Hendrie, Hugh C.,
Callahan, Chris M.,
Boustani, Malaz A.
Background: The class of acetylcholinesterase inhibitors (ChEI), including donepezil, rivastigmine, and galantamine, have similar efficacy profiles in patients with mild to moderate Alzheimer’s disease (AD). However, few studies have evaluated adherence to these agents. We sought to prospectively capture the rates and reasons for nonadherence to ChEI and determine factors influencing tolerability and adherence.; Methods/design: […]
Psychosocial group intervention to enhance self-management skills of people with dementia and their caregivers: study protocol for a randomized controlled trial
Laakkonen, Marja-Liisa,
Hölttä, Eeva H.,
Savikko, Niina,
Strandberg, Timo E.,
Suominen, Merja,
Pitkälä, Kaisu H.
Background: After diagnosis of a dementing illness, patients and their spouses have many concerns related to the disease and their future. This often leads to poor psychological well-being and reduced health-related quality of life (HRQoL) of the family. Support for self-management skills has been proven to be an effective method to improve prognosis of asthma, […]
Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)
Clare, Linda,
Bayer, Antony,
Burns, Alistair,
Corbett, Anne,
Jones, Roy,
Knapp, Martin,
Kopelman, Michael,
Kudlicka, Aleksandra,
Leroi, Iracema,
Oyebode, Jan,
Pool, Jackie,
Woods, Bob,
Whitaker, Rhiannon
Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer’s disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers.; Methods/design: In this multi-centre, single-blind […]