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This database contains 140 studies, archived under the term: "Depression and Anxiety"

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Rivastigmine for mild cognitive impairment in Parkinson disease: a placebo-controlled study

Mild cognitive impairment (MCI) in Parkinson’s disease (PD) may be associated with subtle functional impairment and worse quality of life. The objective of this study was to determine the efficacy and tolerability of rivastigmine for PD-MCI. Patients with PD-MCI (n = 28) were enrolled in a 24-week, randomized, double-blind, placebo-controlled, crossover, single-site study of the rivastigmine transdermal […]

Effects of multisensory stimulation on cognition, depression and anxiety levels of mildly-affected Alzheimer’s patients

Aims: The purpose of this study was to investigate and assess the effects of musical therapy, painting inanimate–animate object pictures, and orientation to time–place–person interventions on the cognitive state, depression, and anxiety levels of mildly-affected Alzheimer’s patients. Methods: The study using a quasi-experimental design was conducted with 27 mildly-affected Alzheimer’s patients. The effects of the […]

Effectiveness of an individualized functional training program on affective disturbances and functional skills in mild and moderate dementia—A randomized control trial

Objectives: We reported the findings of a randomized controlled trial (RCT) to examine the effects of an individualized functional enhancement program (FEP) on functional skills and mood symptoms in mild and moderate dementia. Subjects & Methods: 74 Chinese older persons with dementia were recruited into a skills training program by occupational therapists (OT). Thirty seven […]

Evaluation of a TEACCH- and music therapy-based psychological intervention in mild to moderate dementia: A controlled trial

Background: A multicomponent psychological intervention designed to alleviate neuropsychiatric symptoms and to improve communication in mild to moderate dementia was evaluated in a controlled trial. Components were (1) TEACCH (Treatment and Education of Autistic and related Communication handicapped Children)-based cognitive-behavioral and environmental interventions adapted for dementia and (2) music therapy. Methods: In a Pre-post design, […]

Efficacy and tolerability of Ginkgo biloba extract EGb 761® by type of dementia: Analyses of a randomised controlled trial

Secondary analyses of a randomised controlled trial were performed to find out whether treatment effects of Ginkgo biloba extract EGb 761® differed by type of dementia. Three hundred ninety-five patients aged 50 years or above, with dementia with neuropsychiatric features were treated with EGb 761® (240 mg/day) or placebo for 22 weeks. Patients scored between […]

Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial

Context: Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. Objective: To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. Design and Setting: Randomized controlled trial of a 24-week physical activity intervention conducted between 2004 and […]

De invloed van Dementia Care Mapping (DCM) op moeilijk hanteerbaar gedrag van mensen met dementie en de arbeidstevredenheid van verzorgenden: Een pilotstudie. = The influence of Dementia Care Mapping (DCM) on behavioural problems of persons with dementia and the job satisfaction of caregivers: A pilot study

The prevalence of behavioural problems in nursing home residents with dementia is high. Knowledge based on practical experiences suggests that problems diminish when caregivers are better able to recognize and acknowledge the individual psychosocial needs of residents. Dementia Care Mapping (DCM) is a method designed to support caregivers in providing person centered care. After implementing […]

Musical structural determinants of emotional judgments in dementia of the Alzheimer type

People with dementia of the Alzheimer type (DAT) may well be emotionally soothed by listening to music. However, very few systematic studies have been conducted to support the anecdotal evidence. DAT does damage certain cerebral structures that subsume emotional processing, and some studies have demonstrated deficits affecting emotional judgments of facial expression and prosody in […]

Long-term treatment of patients with Alzheimer’s disease in primary and secondary care: Results from an international survey

Objective: The International Outcomes Survey in Dementia (IOSID) was initiated to observe the effects of current standard of care for Alzheimer’s disease (AD) on patient outcomes and caregiver burden in a real-life setting. Research design and methods: This 2-year, international, prospective, longitudinal and observational cohort survey involved patients with mild-to-moderate AD (Mini-Mental State Examination [MMSE] […]

Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial

Cost-effective strategies to maintain healthy active lifestyle in aging populations are required to address the global burden of age-related diseases. ASPREE will examine whether the potential primary prevention benefits of low dose aspirin outweigh the risks in older healthy individuals. Our primary hypothesis is that daily oral 100 mg enteric-coated aspirin will extend a composite […]

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