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A proteomics study reveals a predominant change in MaoB expression in platelets of healthy volunteers after high protein meat diet: relationship to the methylation cycle
Zellner, Maria,
Babeluk, Rita,
Jakobsen, Lene H.,
Gerner, Christopher,
Umlauf, Ellen,
Volf, Ivo,
Roth, Erich,
Kondrup, Jens
Studies investigating the impact of high meat intake on cognition have yielded contradictory results as some show improved cognitive performance, whereas others report an increase of risk factors for dementia. However, few studies were designed to directly assess the effect of a high protein (HP) diet on both cognitive performance and corresponding biochemical parameters. A […]
DHEA and cognition in HIV-positive patients with non-major depression
Background: Dihydroepiandrosterone (DHEA) has been investigated for its potential role in improving cognition in a number of patient populations. Treatment options are limited for HIV-associated neurocognitive disorders.; Objective: The authors tested the effect of DHEA administration on the cognitive functioning of HIV-positive subjects with non-major depression.; Method: The neuropsychological testing data for 60 HIV-positive patients […]
The costs and benefits of an integrated approach to dementia
Wolfs, C. A. G.,
Dirksen, C. D.,
Severens, J. L.,
Kessels, A.,
Verkaaik, M.,
Verhey, F. R. J.
Background: An integrated approach to dementia is generally recommended because no one discipline is adequately equipped it deal with the complex psychic, physical and social problems that are inherent in dementia. A multidisciplinary approach, however, leads inevitably to higher costs. It is not known what the cost/benefit ratio will be.; Aim: To describe our research […]
Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women’s Health Initiative Memory Study
Goveas, Joseph S.,
Hogan, Patricia E.,
Kotchen, Jane M.,
Smoller, Jordan W.,
Denburg, Natalie L.,
Manson, JoAnn E.,
Tummala, Aruna,
Mysiw, W. Jerry,
Ockene, Judith K.,
Woods, Nancy F.,
Espeland, Mark A.,
Wassertheil-Smoller, Sylvia
Background: Antidepressants are commonly prescribed medications in the elderly, but their relationship with incident mild cognitive impairment (MCI) and probable dementia is unknown.; Methods: The study cohort included 6,998 cognitively healthy, postmenopausal women, aged 65-79 years, who were enrolled in a hormone therapy clinical trial and had baseline depressive symptoms and antidepressant use history assessments […]
Effectivity of early psychosocial counselling for family caregivers in general practioner based dementia care
Geschke, K.,
Scheurich, A.,
Schermuly, I.,
Laux, N.,
Böttcher, A.,
Fellgiebel, A.
Background: Psychoeducation and professional support of family caregivers are regarded as important aspects in dementia care. In the context of a general practitioner’s (GP) based dementia care project we investigated if professional counselling after making a diagnosis of dementia can reduce the development of depression in family caregivers.; Methods: 42 patients with dementia and their […]
Physical training improves motor performance in people with dementia: a randomized controlled trial
Hauer, Klaus,
Schwenk, Michael,
Zieschang, Tania,
Essig, Marco,
Becker, Clemens,
Oster, Peter
Objectives: To determine whether a specific, standardized training regimen can improve muscle strength and physical functioning in people with dementia.; Design: Double-blinded, randomized, controlled trial with 3-month intervention and 3-month follow-up period in 2006 to 2009.; Setting: Outpatient geriatric rehabilitation.; Participants: Individuals with confirmed mild to moderate dementia, no severe somatic or psychological disease, and […]
Non-invasive brain stimulation improves object-location learning in the elderly
Flöel, Agnes,
Suttorp, Wiebke,
Kohl, Oliver,
Kürten, Julia,
Lohmann, Hubertus,
Breitenstein, Caterina,
Knecht, Stefan
Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean age 62.1 years) right-handed […]