This database contains 52 studies, archived under the term: "research design"
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Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design
Pelton, Gregory H.,
Andrews, Howard,
Roose, Steven P.,
Marcus, Sue M.,
D'Antonio, Kristina,
Husn, Hala,
Petrella, Jeffrey R.,
Zannas, Anthony S.,
Doraiswamy, P. Murali,
Devanand, D. P.
Treatment strategies for patients with depression and cognitive impairment (DEP-CI), who are at high risk to develop a clinical diagnosis of dementia, are not established. This issue is addressed in the donepezil treatment of cognitive impairment and depression (DOTCODE) pilot clinical trial. The DOTCODE study is the first long-term treatment trial that assesses differences in […]
The OPERA trial: protocol for a randomised trial of an exercise intervention for older people in residential and nursing accommodation
Underwood, Martin,
Eldridge, Sandra,
Lamb, Sallie,
Potter, Rachel,
Sheehan, Bartley,
Slowther, Anne-Marie,
Taylor, Stephanie,
Thorogood, Margaret,
Weich, Scott
Background: Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortality. Exercise has potential to improve depression, and has been shown in existing trials to improve outcomes among younger and older people. Existing evidence comes from […]
Feasibility study of an optimised person-centred intervention to improve mental health and reduce antipsychotics amongst people with dementia in care homes: study protocol for a randomised controlled trial
Whitaker, Rhiannon,
Ballard, Clive,
Stafford, Jane,
Orrell, Martin,
Moniz-Cook, Esme,
Woods, Robert T,
Murray, Joanna,
Knapp, Martin,
Carlton, Barbara Woodward,
Fossey, Jane
Background: People living in care homes often have complex mental and physical health problems, disabilities and social needs which are compounded by the use of psychiatric and other drugs. In the UK dementia care is a national priority with a vast impact on services. WHELD combines the most effective elements of existing approaches to develop […]
Peer support for family carers of people with dementia, alone or in combination with group reminiscence in a factorial design: study protocol for a randomised controlled trial
Charlesworth, Georgina,
Burnell, Karen,
Beecham, Jennifer,
Hoare, Zoe,
Hoe, Juanita,
Wenborn, Jennifer,
Knapp, Martin,
Russell, Ian,
Woods, Bob,
Orrell, Martin
Background: Peer support interventions can improve carer wellbeing and interventions that engage both the carer and person with dementia can have significant mutual benefits. Existing research has been criticised for inadequate rigour of design or reporting. This paper describes the protocol for a complex trial that evaluates one-to-one peer support and a group reminiscence programme, […]
Maintenance Cognitive Stimulation Therapy (CST) for dementia: a single-blind, multi-centre, randomized controlled trial of Maintenance CST vs. CST for dementia
Aguirre, Elisa,
Spector, Aimee,
Hoe, Juanita,
Russell, Ian T.,
Knapp, Martin,
Woods, Robert T,
Orrell, Martin
Background: Psychological treatments for dementia are widely used in the UK and internationally, but only rarely have they been standardised, adequately evaluated or systematically implemented. There is increasing recognition that psychosocial interventions may have similar levels of effectiveness to medication, and both can be used in combination. Cognitive Stimulation Therapy (CST) is a 7-week cognitive-based […]
Self-management in early-stage dementia: a pilot randomised controlled trial of the efficacy and cost-effectiveness of a self-management group intervention (the SMART study)
Quinn, Catherine,
Anderson, Daniel,
Toms, Gill,
Whitaker, Rhiannon,
Edwards, Rhiannon Tudor,
Jones, Carys,
Clare, Linda
Background: The possibility of living well with a long-term condition has been identified as centrally relevant to the needs of people living with dementia. Growing numbers of people with early-stage dementia are contributing accounts that emphasise the benefits of actively engaging in managing the condition. Self-management interventions share the common objectives of educating about the […]
Does telecare prolong community living in dementia? A study protocol for a pragmatic, randomised controlled trial
Leroi, Iracema,
Woolham, John,
Gathercole, Rebecca,
Howard, Robert,
Dunk, Barbara,
Fox, Chris,
O'Brien, John,
Bateman, Andrew,
Poland, Fiona,
Bentham, Peter,
Burns, Alistair,
Davies, Anna,
Forsyth, Kirsty,
Gray, Richard,
Knapp, Martin,
Newman, Stanton,
McShane, Rupert,
Ritchie, Craig
Background: Assistive technology and telecare (ATT) are relatively new ways of delivering care and support to people with social care needs. It is claimed that ATT reduces the need for community care, prevents unnecessary hospital admission, and delays or prevents admission into residential or nursing care. The current economic situation in England has renewed interest […]
Maintenance Cognitive Stimulation Therapy (CST) in practice: study protocol for a randomized controlled trial
Streater, Amy,
Spector, Aimee,
Aguirre, Elisa,
Hoe, Juanita,
Hoare, Zoe,
Woods, Robert,
Russell, Ian,
Orrell, Martin
Background: Cognitive Stimulation Therapy (CST) is a psychosocial evidence-based group intervention for people with dementia recommended by the UK NICE guidelines. In clinical trials, CST has been shown to improve cognition and quality of life, but little is known about the best way of ensuring implementation of CST in practice settings. A recent pilot study […]
Improving psychotropic drug prescription in nursing home patients with dementia: design of a cluster randomized controlled trial
Smeets, Claudia H. W.,
Smalbrugge, Martin,
Gerritsen, Debby L,
Nelissen-Vrancken, Marjorie H. J. M. G.,
Wetzels, Roland B.,
van der Spek, Klaas,
Zuidema, Sytse U.,
Koopmans, Raymond T. C. M.
Background: Neuropsychiatric symptoms are highly prevalent in nursing home patients with dementia. Despite modest effectiveness and considerable side effects, psychotropic drugs are frequently prescribed for these neuropsychiatric symptoms. This raises questions whether psychotropic drugs are appropriately prescribed. The aim of the PROPER (PRescription Optimization of Psychotropic drugs in Elderly nuRsing home patients with dementia) II […]
Implementatie, effecten en kosten van casemanagement voor mensen met dementie en hun mantelzorgers: Beschrijving van de COMPAS studie. = Comparing case management care models for people with dementia and their caregivers: The design of the COMPAS study
van Hout, H. P. J.,
Macneil Vroomen, J. L.,
Van Mierlo, L. D.,
Meiland, F. J. M.,
Moll van Charante, E. P.,
Joling, K. J.,
van den Dungen, P.,
Dröes, R. M.,
van der Horst, H. E.,
de Rooij, S. E. J. A.
Background: Dementia care in The Netherlands is shifting from fragmented, ad hoc care to more coordinated and personalized care. Case management contributes to this shift. The linkage model and a combination of intensive case management and joint agency care models were selected based on their emerging prominence in The Netherlands. It is unclear if these […]