This database contains 80 studies, archived under the term: "of"
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PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease
Sabbagh, Marwan N.,
Agro, Albert,
Bell, Joanne,
Aisen, Paul S,
Schweizer, Edward,
Galasko, Douglas
Objective: To evaluate the safety and tolerability of PF-04494700, an oral inhibitor of receptor for advanced glycation end products, in patients with mild-to-moderate dementia of the Alzheimer type.; Methods: Patients aged 50 years and older who met the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer’s Disease and Related Disorders Association criteria for Alzheimer […]
Prospective flutemetamol positron emission tomography and histopathology in normal pressure hydrocephalus
Rinne, Juha O.,
Frantzen, Janek,
Leinonen, Ville,
Lonnrot, Kimmo,
Laakso, Aki,
Virtanen, Kirsi A.,
Solin, Olof,
Kotkansalo, Anna,
Koivisto, Anne,
Sajanti, Juha,
Karppinen, Atte,
Lehto, Hanna,
Rummukainen, Jaana,
Buckley, Chris,
Smith, Adrian,
Jones, Paul A.,
Sherwin, Paul,
Farrar, Gill,
McLain, Richard,
Kailajarvi, Marita,
Grachev, Igor D.
Unlabelled: BACKGOUND/OBJECTIVE: To determine the level of association between uptake of the amyloid positron emission tomography (PET) imaging agent [(18)F]flutemetamol and the level of amyloid-β measured by immunohistochemical and histochemical staining in a frontal cortical region biopsy site.; Methods: Seventeen patients with probable normal pressure hydrocephalus (NPH) underwent prospective [(18)F]flutemetamol PET and subsequent frontal cortical […]
The ALS-FTD-Q: a new screening tool for behavioral disturbances in ALS
Raaphorst, Joost,
Beeldman, Emma,
Schmand, Ben,
Berkhout, Joris,
Linssen, Wim H. J. P.,
van den Berg, Leonard H.,
Pijnenburg, Yolande A.,
Grupstra, Hepke F.,
Weikamp, Janneke G.,
Schelhaas, H. Jurgen,
Papma, Janne M.,
van Swieten, John C.,
de Visser, Marianne,
de Haan, Rob J.
Objective: The assessment of behavioral disturbances in amyotrophic lateral sclerosis (ALS) is important because of the overlap with the behavioral variant of frontotemporal dementia (ALS-bvFTD). Motor symptoms and dysarthria are not taken into account in currently used behavioral questionnaires. We examined the clinimetric properties of a new behavioral questionnaire for patients with ALS (Amyotrophic Lateral […]
Fetal striatal grafting slows motor and cognitive decline of Huntington’s disease
Paganini, M.,
Biggeri, A.,
Romoli, A. M.,
Mechi, C.,
Ghelli, E.,
Berti, V.,
Pradella, S.,
Bucciantini, S.,
Catelan, D.,
Saccardi, R.,
Lombardini, L.,
Mascalchi, M.,
Massacesi, L.,
Porfirio, B.,
Di Lorenzo, N.,
Vannelli, G. B.,
Gallina, P.
Objective: To assess the clinical effect of caudate-putaminal transplantation of fetal striatal tissue in Huntington’s disease (HD).; Methods: We carried out a follow-up study on 10 HD transplanted patients and 16 HD not-transplanted patients. All patients were evaluated with the Unified HD Rating Scale (UHDRS) whose change in motor, cognitive, behavioural and functional capacity total […]
Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study
O'Callaghan, Nathan,
Parletta, Natalie,
Milte, Catherine M.,
Benassi-Evans, Bianca,
Fenech, Michael,
Howe, Peter R.C.
Objectives: Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging. Oxidative stress and nutritional deficiency may influence this process. The aim of this study was to investigate the effect of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on telomeric shortening in elderly individuals with mild cognitive impairment (MCI).; Methods: Thirty-three […]
Encouraging lifestyle behaviour change in mild cognitive impairment patients: Development of appropriate educational material
Neville, Charlotte E.,
McCourt, Hannah J.,
McKinley, Michelle C.,
Lowis, Carole,
Barrett, Suzanne L.,
McGuinness, Bernadette,
Todd, Stephen,
Lawlor, Brian,
Gibb, Matthew,
Coen, Robert F.,
Passmore, Anthony P.,
Woodside, Jayne V.
Objectives: A healthy lifestyle may help maintain cognitive function and reduce the risk of developing dementia. This study employed a focus group approach in order to gain insight into opinions of mild cognitive impairment (MCI) patients, caregivers (CG) and health professionals (HP) regarding lifestyle and its relationship with cognition. The qualitative data were used to […]
Cost-effectiveness of one year dementia follow-up care by memory clinics or general practitioners: economic evaluation of a randomised controlled trial
Meeuwsen, Els,
Melis, René,
van der Aa, Geert,
Golüke-Willemse, Gertie,
de Leest, Benoit,
van Raak, Frank,
Schölzel-Dorenbos, Carla,
Verheijen, Desiree,
Verhey, Frans,
Visser, Marieke,
Wolfs, Claire,
Adang, Eddy,
Olde Rikkert, Marcel
Objective: To evaluate the cost-effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared to general practitioners’ care.; Methods: A multicentre randomised trial with 175 community dwelling patients newly diagnosed with mild to moderate dementia, and their informal caregivers, with twelve months’ follow-up. Cost-effectiveness was evaluated from a societal point of view […]
Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women’s Health Initiative randomized trials
Manson, JoAnn E.,
Chlebowski, Rowan T.,
Stefanick, Marcia L.,
Aragaki, Aaron K.,
Rossouw, Jacques E.,
Prentice, Ross L.,
Anderson, Garnet,
Howard, Barbara V.,
Thomson, Cynthia A.,
LaCroix, Andrea Z.,
Wactawski-Wende, Jean,
Jackson, Rebecca D.,
Limacher, Marian,
Margolis, Karen L.,
Wassertheil-Smoller, Sylvia,
Beresford, Shirley A.,
Cauley, Jane A.,
Eaton, Charles B.,
Gass, Margery,
Hsia, Judith,
Johnson, Karen C.,
Kooperberg, Charles,
Kuller, Lewis H.,
Lewis, Cora E.,
Liu, Simin,
Martin, Lisa W.,
Ockene, Judith K.,
O’Sullivan, Mary Jo,
Powell, Lynda H.,
Simon, Michael S.,
Van Horn, Linda,
Vitolins, Mara Z.,
Wallace, Robert B.
Importance: Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention.; Objective: To report a comprehensive, integrated overview of findings from the 2 Women’s Health Initiative (WHI) hormone therapy trials with extended postintervention follow-up.; Design, Setting, and Participants: A total of 27,347 postmenopausal women aged 50 […]