This database contains 366 studies, archived under the term: "methods"
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Early intervention for mild cognitive impairment: a randomised controlled trial
Kinsella, G. J.,
Mullaly, E.,
Rand, E.,
Ong, B.,
Burton, C.,
Price, S.,
Phillips, M.,
Storey, E.
Background: Positive effects are reported for memory training for healthy older adults, and yet there is limited information about the benefit of cognitive intervention for older adults with increasing memory difficulties-mild cognitive impairment.; Objective: To investigate the usefulness of an early cognitive intervention for the memory difficulties experienced by people with amnestic mild cognitive impairment.; […]
Video programming for individuals with dementia: assessing cognitive congruence
The effect of cognitively congruent video programming on attentional engagement, as measured by the average look duration and the proportion of the video viewed, was examined among long-term care facility residents with Alzheimer’s disease. Over a 2-week period, 24 residents viewed 4 cognitively congruent videos and 1 control video (ie, a recorded episode of a […]
Preserving cognition through an integrated cognitive stimulation and training program
Background: Cognitive decline leads to disability and increased health care expenditures.; Methods: Effectiveness of an intervention to stimulate multiple cognitive domains was determined using a format combining traditional and computer-based activities (Integrated Cognitive Stimulation and Training Program), 45 minutes a day, 2 days a week, for 6 weeks. Nonimpaired, mildly, and moderately-impaired participants > age […]
Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial
Doody, R. S.,
Ferris, S. H.,
Salloway, S.,
Sun, Y.,
Goldman, R.,
Watkins, W. E.,
Xu, Y.,
Murthy, A. K.
Background: Treatment of mild cognitive impairment (MCI) with cholinesterase inhibitors may improve symptoms.; Methods: In this multicenter, randomized, placebo-controlled trial, subjects with MCI entered a 3-week placebo run-in period followed by 48 weeks of double-blind donepezil (5 mg/day for 6 weeks, then 10 mg/day for 42 weeks) or placebo treatment. Primary efficacy variables included change […]
Non-pharmacological management of behavioural symptoms in nursing homes
Deudon, Audrey,
Maubourguet, Nathalie,
Gervais, Xavier,
Leone, Elsa,
Brocker, Patrice,
Carcaillon, Laure,
Riff, Simone,
Lavallart, Benoît,
Robert, Philippe Henri
Background: Behavioural and psychological symptoms of dementia (BPSD) are often reported in institutions for the elderly.; Objective: To evaluate the effectiveness of a staff education intervention to manage BPSD in older people with a diagnosis of dementia.; Methods: The trial was conducted in 16 nursing homes; 306 patients with a diagnosis of dementia and presenting […]
An exploratory cluster randomized controlled trial of group exercise on mobility and depression in care home residents
Brittle, Nicola,
Patel, Smitaa,
Wright, Christine,
Baral, Sabrina,
Versfeld, Pam,
Sackley, Catherine
Objective: To investigate the feasibility, acceptability and potential efficacy of group exercise for residents in care homes.; Design: Exploratory cluster randomized controlled trial.; Setting: Five randomly selected care homes in South Birmingham, UK.; Participants: Fifty-six care home residents (mean age 84.5, 71% female), 39 (70%) with cognitive impairments.; Intervention: Two homes (n = 28) were […]
Decreased activation along the dorsal visual pathway after a 3-month treatment with galantamine in mild Alzheimer disease: a functional magnetic resonance imaging study
Bokde, Arun L. W.,
Karmann, Michaela,
Teipel, Stefan J.,
Born, Christine,
Lieb, Martin,
Reiser, Maximilian F.,
Möller, Hans-Jürgen,
Hampel, Harald
Visual perception has been shown to be altered in Alzheimer disease (AD) patients, and it is associated with decreased cognitive function. Galantamine is an active cholinergic agent, which has been shown to lead to improved cognition in mild to moderate AD patients. This study examined brain activation in a group of mild AD patients after […]
Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial
Barnes, Deborah E.,
Yaffe, Kristine,
Belfor, Nataliya,
Jagust, William J.,
DeCarli, Charles,
Reed, Bruce R.,
Kramer, Joel H.
We performed a pilot randomized, controlled trial of intensive, computer-based cognitive training in 47 subjects with mild cognitive impairment. The intervention group performed exercises specifically designed to improve auditory processing speed and accuracy for 100 min/d, 5 d/wk for 6 weeks; the control group performed more passive computer activities (reading, listening, visuospatial game) for similar […]