This database contains 1058 studies, archived under the term: "aged"
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Study of the effects of vinpocetin on cognitive functions
Introduction: Chronic cerebral hypoperfusion is a risk factor for the development of certain types of dementia. Mild cognitive impairment is a stage of predementia condition, because the symptoms are similar but not as severe as the symptoms in patients with dementia. Vinpocetine, due to its complex mechanism of action, has an important role in the […]
Comparison of pharmacokinetics, pharmacodynamics, safety, and tolerability of the amyloid β monoclonal antibody solanezumab in Japanese and white patients with mild to moderate alzheimer disease
Uenaka, Kazunori,
Nakano, Masako,
Willis, Brian A.,
Friedrich, Stuart,
Ferguson-Sells, Lisa,
Dean, Robert A.,
Ieiri, Ichiro,
Siemers, Eric R.
Objectives: Solanezumab is a humanized anti-amyloid β monoclonal antibody being developed as a passive immunization treatment to slow the progression of Alzheimer disease (AD). Pharmacokinetics (PK), pharmacodynamics, safety, and tolerability after a single dose of solanezumab were compared between Japanese and white patients with AD.; Methods: Japanese and white patients with mild to moderate AD […]
Dietary patterns are associated with cognition among older people with mild cognitive impairment
Torres, Susan J.,
Lautenschlager, Nicola T.,
Wattanapenpaiboon, Naiyana,
Greenop, Kathryn R.,
Beer, Christopher,
Flicker, Leon,
Alfonso, Helman,
Nowson, Caryl A.
There has been increasing interest in the influence of diet on cognition in the elderly. This study examined the cross-sectional association between dietary patterns and cognition in a sample of 249 people aged 65-90 years with mild cognitive impairment (MCI). Two dietary patterns; whole and processed food; were identified using factor analysis from a 107-item; […]
Cognitive intervention response is related to habitual physical activity in older adults
Thiel, Christian,
Vogt, Lutz,
Tesky, Valentina A.,
Meroth, Linda,
Jakob, Marion,
Sahlender, Sandra,
Pantel, Johannes,
Banzer, Winfried
Background and Aims: This study analysed the associations between physical activity and the effects of cognitive training on perceived cognitive functioning and life satisfaction in older adults.; Methods: A sample of 114 intervention group participants (65-89 yrs) received weekly group sessions of cognitive stimulation for two months. This sample was stratified into groups according to […]
Effect of a human-type communication robot on cognitive function in elderly women living alone
Tanaka, Masaaki,
Ishii, Akira,
Yamano, Emi,
Ogikubo, Hiroki,
Okazaki, Masatsugu,
Kamimura, Kazuro,
Konishi, Yasuharu,
Emoto, Shigeru,
Watanabe, Yasuyoshi
Background: Considering the high prevalence of dementia, it would be of great value to develop effective tools to improve cognitive function. We examined the effects of a human-type communication robot on cognitive function in elderly women living alone.; Material/methods: In this study, 34 healthy elderly female volunteers living alone were randomized to living with either […]
Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial
Suzuki, Takao,
Shimada, Hiroyuki,
Makizako, Hyuma,
Doi, Takehiko,
Yoshida, Daisuke,
Tsutsumimoto, Kota,
Anan, Yuya,
Uemura, Kazuki,
Lee, Sangyoon,
Park, Hyuntae
Background: To examine the effects of a multicomponent exercise program on the cognitive function of older adults with amnestic mild cognitive impairment (aMCI).; Design: Twelve months, randomized controlled trial;; Setting: Community center in Japan;; Participants: Fifty older adults (27 men) with aMCI ranging in age from 65 to 93 years (mean age, 75 years);; Intervention: […]