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Study of the effects of vinpocetin on cognitive functions


Valikovics, Attila, Csányi, Attila, Németh, László


Ideggyógyászati Szemle, Volume: 65, No.: 3-4, Pages.: 115-120

Year of Publication



Introduction: Chronic cerebral hypoperfusion is a risk factor for the development of certain types of dementia. Mild cognitive impairment is a stage of predementia condition, because the symptoms are similar but not as severe as the symptoms in patients with dementia. Vinpocetine, due to its complex mechanism of action, has an important role in the improvement of chronic cerebral hypoperfusion.; Objectives: The aim of our study was to determine the severity of the cognitive decline and to investigate the efficacy and safety of per os 18 months vinpocetine treatment in patients with mild cognitive impairment.; Methods: We used psychometrical tests (MMSE, ADAS-Cog) to assess the cognitive functions. CGIC-PGIC was used to evaluate the overall change in the disease status. ADL was used to assess the patient’s daily activity and the Hamilton Depression Scale to evaluate the patient’s mood. The assessments were performed at six visits during the 18 months treatment period.; Results: At the beginning of the treatment, the stage of our patients’ mild cognitive impairment was moderately severe. Significant improvement was detected in the psychometrical tests after the 18 months treatment period. The overall status of the disease improved significantly according both to the patient and the investigator. Also significant improvement was detected in daily activity. The complex improvement of the clinical symptoms affected the patients’ mood positively. Moreover, vinpocetine was safe and had a good tolerability during the whole study period.; Conclusions: Vinpocetine, due its complex mechanism of action, improved significantly the cognitive functions, overall disease status and quality of life in patients with chronic cerebral hypoperfusion. As a result, vinpocetine treatment can be recommended for patients with mild cognitive impairment.;


administration & dosage, administration oral, adult, adverse effects, aged, cerebrovascular circulation, cognition, dementia, drug administration schedule, drug effects, drug therapy, female, humans, male, middle aged, mild cognitive impairment, neuroprotective agents, nootropic agents, prevention & control, psychology, psychometrics, quality of life, severity of illness index, therapeutic use, treatment outcome, vasodilator agents, vinca alkaloids, vinpocetine

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Cohort Study

Type of Outcomes

ADLs/IADLs, Cognition, Depression and Anxiety

Type of Interventions

Pharmaceutical Interventions