This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial


Suzuki, Takao, Shimada, Hiroyuki, Makizako, Hyuma, Doi, Takehiko, Yoshida, Daisuke, Tsutsumimoto, Kota, Anan, Yuya, Uemura, Kazuki, Lee, Sangyoon, Park, Hyuntae


BMC Neurology, Volume: 12, Pages.: 128-128

Year of Publication



Background: To examine the effects of a multicomponent exercise program on the cognitive function of older adults with amnestic mild cognitive impairment (aMCI).; Design: Twelve months, randomized controlled trial;; Setting: Community center in Japan;; Participants: Fifty older adults (27 men) with aMCI ranging in age from 65 to 93 years (mean age, 75 years);; Intervention: Subjects were randomized into either a multicomponent exercise (n = 25) or an education control group (n = 25). Subjects in the multicomponent exercise group exercised under the supervision of physiotherapists for 90 min/d, 2 d/wk, for a total of 80 times over 12 months. The exercises included aerobic exercises, muscle strength training, and postural balance retraining, and were conducted using multiple conditions to stimulate cognitive functions. Subjects in the control group attended three education classes regarding health during the 12-month period. MEASUREMENTS were administered before, after the 6-month, and after the 12-month intervention period;; Measurements: The performance measures included the mini-mental state examination, logical memory subtest of the Wechsler memory scale-revised, digit symbol coding test, letter and categorical verbal fluency test, and the Stroop color word test.; Results: The mean adherence to the exercise program was 79.2%. Improvements of cognitive function following multicomponent exercise were superior at treatment end (group × time interactions for the mini-mental state examination (P = 0.04), logical memory of immediate recall (P = 0.03), and letter verbal fluency test (P = 0.02)). The logical memory of delayed recall, digit symbol coding, and Stroop color word test showed main effects of time, although there were no group × time interactions.; Conclusions: This study indicates that exercise improves or supports, at least partly, cognitive performance in older adults with aMCI.;

Bibtex Citation

@article{Suzuki_2012, doi = {10.1186/1471-2377-12-128}, url = {}, year = 2012, month = {oct}, publisher = {Springer Nature}, volume = {12}, number = {1}, author = {Takao Suzuki and Hiroyuki Shimada and Hyuma Makizako and Takehiko Doi and Daisuke Yoshida and Kota Tsutsumimoto and Yuya Anan and Kazuki Uemura and Sangyoon Lee and Hyuntae Park}, title = {Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial}, journal = {{BMC} Neurology} }


aged, aged, 80 and over, amnesia, cognition, executive function, exercise therapy, female, humans, male, memory, methods, mild cognitive impairment, neuropsychological tests, postural balance, psychology, rehabilitation, treatment outcome

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Randomised Controlled Trial

Type of Outcomes




Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Exercise (inc. dancing)