This database contains 1058 studies, archived under the term: "aged"
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Alzheimer’s disease multiple intervention trial (ADMIT): study protocol for a randomized controlled clinical trial
Callahan, Christopher M.,
Boustani, Malaz A.,
Schmid, Arlene A.,
Austrom, Mary G.,
Miller, Douglas K.,
Gao, Sujuan,
Morris, Carrie S.,
Vogel, Mickey,
Hendrie, Hugh C.
Background: Given the current lack of disease-modifying therapies, it is important to explore new models of longitudinal care for older adults with dementia that focus on improving quality of life and delaying functional decline. In a previous clinical trial, we demonstrated that collaborative care for Alzheimer’s disease reduces patients’ neuropsychiatric symptoms as well as caregiver […]
DHEA and cognition in HIV-positive patients with non-major depression
Background: Dihydroepiandrosterone (DHEA) has been investigated for its potential role in improving cognition in a number of patient populations. Treatment options are limited for HIV-associated neurocognitive disorders.; Objective: The authors tested the effect of DHEA administration on the cognitive functioning of HIV-positive subjects with non-major depression.; Method: The neuropsychological testing data for 60 HIV-positive patients […]
The costs and benefits of an integrated approach to dementia
Wolfs, C. A. G.,
Dirksen, C. D.,
Severens, J. L.,
Kessels, A.,
Verkaaik, M.,
Verhey, F. R. J.
Background: An integrated approach to dementia is generally recommended because no one discipline is adequately equipped it deal with the complex psychic, physical and social problems that are inherent in dementia. A multidisciplinary approach, however, leads inevitably to higher costs. It is not known what the cost/benefit ratio will be.; Aim: To describe our research […]
Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women’s Health Initiative Memory Study
Goveas, Joseph S.,
Hogan, Patricia E.,
Kotchen, Jane M.,
Smoller, Jordan W.,
Denburg, Natalie L.,
Manson, JoAnn E.,
Tummala, Aruna,
Mysiw, W. Jerry,
Ockene, Judith K.,
Woods, Nancy F.,
Espeland, Mark A.,
Wassertheil-Smoller, Sylvia
Background: Antidepressants are commonly prescribed medications in the elderly, but their relationship with incident mild cognitive impairment (MCI) and probable dementia is unknown.; Methods: The study cohort included 6,998 cognitively healthy, postmenopausal women, aged 65-79 years, who were enrolled in a hormone therapy clinical trial and had baseline depressive symptoms and antidepressant use history assessments […]
Effectivity of early psychosocial counselling for family caregivers in general practioner based dementia care
Geschke, K.,
Scheurich, A.,
Schermuly, I.,
Laux, N.,
Böttcher, A.,
Fellgiebel, A.
Background: Psychoeducation and professional support of family caregivers are regarded as important aspects in dementia care. In the context of a general practitioner’s (GP) based dementia care project we investigated if professional counselling after making a diagnosis of dementia can reduce the development of depression in family caregivers.; Methods: 42 patients with dementia and their […]
A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects
Dockens, Randy,
Wang, Jun-Sheng,
Castaneda, Lorna,
Sverdlov, Oleksandr,
Huang, Shu-Pang,
Slemmon, Randy,
Gu, Huidong,
Wong, Oi,
Li, Hewei,
Berman, Robert M.,
Smith, Christina,
Albright, Charles F.,
Tong, Gary
Background and Objectives: Avagacestat is an orally active γ-secretase inhibitor that selectively inhibits amyloid β (Aβ) synthesis in cell culture and animal models. The objective of the current study was to assess the pharmacokinetics, pharmacodynamics, safety and tolerability of multiple doses of avagacestat over 28 days in healthy young men and elderly men and women […]