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Three-week nutritional supplementation effect on long-term nutritional status of patients with mild Alzheimer disease


de Sousa, Odete Luísa Vicente, Amaral, Teresa F.


Alzheimer Disease And Associated Disorders, Volume: 26, No.: 2, Pages.: 119-123

Year of Publication



Short-term nutritional supplements enable an improvement in Alzheimer patients’ nutritional status, but it remains to be seen whether they will be sufficient to improve long-term nutritional status. The aim of this study was to evaluate the long-term impact of a 3-week nutritional supplementation on the nutritional status of undernourished patients with probable mild Alzheimer disease. A 21-day prospective randomized nonblinded controlled trial was conducted. Patients were followed-up for an additional period until the 90th day after the beginning of the intervention. Intervention resulted in significant improvements in Mini Nutritional Assessment (MNA) score [Mean=1.4, standard deviation (SD)=0.8 vs. 0.0 (0.1) in the control group, P<0.001] and also in anthropometrical and serum biomarkers of Alzheimer disease (AD) patients' nutritional status. Further improvements in the AD patients' MNA mean score=1.4 (SD=2.3) versus -0.5 (SD=0.6) in the control group (P=0.003) were seen at 90 days follow-up. Data show that a 3-week nutritional supplementation has a positive long-term impact on the nutritional status of undernourished patients with mild probable AD.;

Bibtex Citation

@article{de_Sousa_2012, doi = {10.1097/wad.0b013e31822c5bb3}, url = {}, year = 2012, publisher = {Ovid Technologies (Wolters Kluwer Health)}, volume = {26}, number = {2}, pages = {119--123}, author = {Odete Lu{'{i}}sa Vicente de Sousa and Teresa F. Amaral}, title = {Three-week Nutritional Supplementation Effect on Long-term Nutritional Status of Patients With Mild Alzheimer Disease}, journal = {Alzheimer Disease {&} Associated Disorders} }


aged, aged, 80 and over, alzheimer disease, biological markers, blood, diagnosis, dietary supplements, disease progression, female, followup studies, humans, male, middle aged, nutrition assessment, nutritional, nutritional status, physiopathology, prospective studies, risk factors, status, supplements

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes

Physical Health

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements