This database contains 244 studies, archived under the term: "Cohort Study"
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Safety and effectiveness of donepezil on behavioral symptoms in patients with Alzheimer disease
The objective of this study was to evaluate the prevalence and treatment responsiveness of neuropsychiatric symptoms in patients with mild to moderately severe Alzheimer disease recruited in a naturalistic treatment setting in Spain. All the patients, who matched the prescribing recommendations for donepezil and were able to participate in the study, received donepezil (5 to […]
Validation of Alzheimer’s disease CSF and plasma biological markers: the multicentre reliability study of the pilot European Alzheimer’s Disease Neuroimaging Initiative (E-ADNI)
Buerger, Katharina,
Frisoni, Giovanni,
Uspenskaya, Olga,
Ewers, Michael,
Zetterberg, Henrik,
Geroldi, Cristina,
Binetti, Giuliano,
Johannsen, Peter,
Rossini, Paolo Maria,
Wahlund, Lars-Olof,
Vellas, Bruno,
Blennow, Kaj,
Hampel, Harald
Background: Alzheimer’s Disease Neuroimaging Initiatives (“ADNI”) aim to validate neuroimaging and biochemical markers of Alzheimer’s disease (AD). Data of the pilot European-ADNI (E-ADNI) biological marker programme of cerebrospinal fluid (CSF) and plasma candidate biomarkers are reported.; Methods: Six academic EADC centres recruited 49 subjects (healthy controls, subjects with mild cognitive impairment (MCI) and AD). We […]
Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins
Brommelhoff, Jessica A.,
Gatz, Margaret,
Johansson, Boo,
McArdle, John J.,
Fratiglioni, Laura,
Pedersen, Nancy L.
This study tested whether history of depression is associated with an increased likelihood of dementia, and whether a first depressive episode earlier in life is associated with increased dementia risk, or whether only depressive episodes close in time to dementia onset are related to dementia. Depression information came from national hospital discharge registries, medical history, […]
Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates
Bondi, Mark W.,
Edmonds, Emily C.,
Jak, Amy J.,
Clark, Lindsay R.,
Delano-Wood, Lisa,
McDonald, Carrie R.,
Nation, Daniel A.,
Libon, David J.,
Au, Rhoda,
Galasko, Douglas,
Salmon, David P.
We compared two methods of diagnosing mild cognitive impairment (MCI): conventional Petersen/Winblad criteria as operationalized by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and an actuarial neuropsychological method put forward by Jak and Bondi designed to balance sensitivity and reliability. 1,150 ADNI participants were diagnosed at baseline as cognitively normal (CN) or MCI via ADNI criteria […]
Olive oil and cognition: results from the three-city study
Berr, Claudine,
Portet, Florence,
Carrière, Isabelle,
Akbaraly, Tasnime N.,
Feart, Catherine,
Gourlet, Véronique,
Combe, Nicole,
Barberger-Gateau, Pascale,
Ritchie, Karen
Background: Olive oil is a major component of the Mediterranean diet suggested to be beneficial to counteract Alzheimer’s disease.; Aim Of the Study: Our objective was to examine the association between olive oil use, cognitive deficit and cognitive decline in a large elderly population.; Methods: We followed 6,947 subjects with a brief baseline food frequency […]
Risk of incident dementia in drug-untreated arterial hypertension: a population-based study
Bermejo-Pareja, Félix,
Benito-León, Julián,
Louis, Elan D.,
Trincado, Rocío,
Carro, Eva,
Villarejo, Alberto,
de la Cámara, Agustín Gómez
Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer’s disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In […]