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Risk of incident dementia in drug-untreated arterial hypertension: a population-based study


Bermejo-Pareja, Félix, Benito-León, Julián, Louis, Elan D., Trincado, Rocío, Carro, Eva, Villarejo, Alberto, de la Cámara, Agustín Gómez


Journal Of Alzheimer's Disease: JAD, Volume: 22, No.: 3, Pages.: 949-958

Year of Publication



Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer’s disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In a population-based study of older people in central Spain (NEDICES), non-demented participants were followed prospectively. Dementia at follow-up was diagnosed using DSM-IV criteria. Using Cox proportional hazards models, the risk of dementia was estimated in participants with drug-untreated hypertension and in participants with drug-treated hypertension versus controls. The 3,824 participants had a mean duration of follow-up of 3.2 years. Sixty-two (3.3%) of 1,870 participants without baseline hypertension developed incident dementia versus 78 (4.7%) of 1,657 with drug-treated, baseline hypertension and 19 (12.0%) with drug-untreated, baseline hypertension. In an unadjusted Cox model, risk of dementia was increased in participants with drug-untreated hypertension (relative risk [RR] =1.93, 95% confidence interval [CI]=1.15–3.23, p = 0.01) and in participants with drug-treated hypertension (RR =1.43, 95% CI= 1.02–2.0, p =0.035) versus participants without hypertension (reference group). In a fully adjusted Cox model, the risk of dementia remained increased in participants with drug-untreated hypertension (RR =2.38, 95% CI =1.32–4.29, p=0.004). Results were similar for risk of AD. Our results suggest that drug-untreated hypertension may be an independent risk factor for dementia and AD in the elderly.;


aged, aged, 80 and over, complications, dementia, epidemiology, etiology, female, humans, hypertension, incidence, male, population surveillance, prospective studies, questionnaires, risk factors

Countries of Study


Types of Dementia

Alzheimer’s Disease, Dementia (general / unspecified)

Types of Study

Cohort Study

Type of Interventions

Risk Factor Modification

Risk Factor Modifications

At risk population