This database contains 250 studies, archived under the term: "Mild Cognitive Impairment (MCI)"
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Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study
O'Callaghan, Nathan,
Parletta, Natalie,
Milte, Catherine M.,
Benassi-Evans, Bianca,
Fenech, Michael,
Howe, Peter R.C.
Objectives: Excessive shortening of the telomeric ends of chromosomes is a marker of accelerated aging. Oxidative stress and nutritional deficiency may influence this process. The aim of this study was to investigate the effect of ω-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on telomeric shortening in elderly individuals with mild cognitive impairment (MCI).; Methods: Thirty-three […]
Validation of the Rowland Universal Dementia Assessment Scale for multicultural screening in Danish memory clinics
Nielsen, T. Rune,
Andersen, Birgitte Bo,
Gottrup, Hanne,
Lützhøft, Jan H.,
Høgh, Peter,
Waldemar, Gunhild
Background/aims: The Rowland Universal Dementia Assessment Scale (RUDAS) is a brief cognitive screening test that was developed to detect dementia in multicultural populations. The RUDAS has not previously been validated in multicultural populations outside of Australia. The aim of this study was to evaluate the diagnostic accuracy of the RUDAS in a multicultural sample of […]
Long-term metformin usage and cognitive function among older adults with diabetes
Ng, Tze Pin,
Feng, Liang,
Yap, Keng Bee,
Lee, Tih Shih,
Tan, Chay Hoon,
Winblad, Bengt
Evidence strongly supports the important role of insulin resistance in cognitive decline and dementia and suggests that insulin sensitizers may protect against cognitive decline in diabetic and pre-diabetic individuals. Inconclusive results have been reported in clinical trials of rosiglitazone, an insulin sensitizer that also increases cardiovascular mortality risks. No study has yet reported a protective […]
Encouraging lifestyle behaviour change in mild cognitive impairment patients: Development of appropriate educational material
Neville, Charlotte E.,
McCourt, Hannah J.,
McKinley, Michelle C.,
Lowis, Carole,
Barrett, Suzanne L.,
McGuinness, Bernadette,
Todd, Stephen,
Lawlor, Brian,
Gibb, Matthew,
Coen, Robert F.,
Passmore, Anthony P.,
Woodside, Jayne V.
Objectives: A healthy lifestyle may help maintain cognitive function and reduce the risk of developing dementia. This study employed a focus group approach in order to gain insight into opinions of mild cognitive impairment (MCI) patients, caregivers (CG) and health professionals (HP) regarding lifestyle and its relationship with cognition. The qualitative data were used to […]
Montreal cognitive assessment performance in patients with Parkinson’s disease with “normal” global cognition according to mini-mental state examination score
Nazem, Sarra,
Siderowf, Andrew D.,
Duda, John E.,
Ten Have, Tom,
Colcher, Amy,
Horn, Stacy S.,
Moberg, Paul J.,
Wilkinson, Jayne R.,
Hurtig, Howard I.,
Stern, Matthew B.,
Weintraub, Daniel
Objectives: To examine Montreal Cognitive Assessment (MoCA) performance in patients with Parkinson’s disease (PD) with “normal” global cognition according to Mini-Mental State Examination (MMSE) score.; Design: A cross-sectional comparison of the MoCA and the MMSE.; Setting: Two movement disorders centers at the University of Pennsylvania and the Philadelphia Veterans Affairs Medical Center.; Participants: A convenience […]
Cognitive training enhances pre-attentive neurophysiological responses in older adults ‘at risk’ of dementia
Mowszowski, Loren,
Hermens, Daniel F.,
Diamond, Keri,
Norrie, Louisa,
Cockayne, Nicole,
Ward, Philip B.,
Hickie, Ian B.,
Lewis, Simon J. G.,
Batchelor, Jennifer,
Naismith, Sharon L.
Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective:We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker […]
Evaluating cognition in an elderly cohort via telephone assessment
Mitsis, Effie M.,
Jacobs, Diane,
Luo, Xiaodong,
Andrews, Howard,
Andrews, Karen,
Sano, Mary
Objective: Longitudinal neuropsychological assessment provides the opportunity to observe the earliest transition to cognitive impairment in healthy, elderly individuals. We examined the feasibility, and its comparability to in-person assessment, of a telephone administered battery of established neuropsychological measures of cognitive functioning in healthy, elderly women.; Methods: Fifty-four women (age = 79 +/- 7.7; education = […]
Visuospatial memory and neuroimaging correlates in mild cognitive impairment
Mitolo, Micaela,
Gardini, Simona,
Fasano, Fabrizio,
Crisi, Girolamo,
Pelosi, Annalisa,
Pazzaglia, Francesca,
Caffarra, Paolo
Spatial abilities decline in normal aging and decrease faster and earlier in Alzheimer’s disease (AD), but these deficits are under investigated. The main goals of this study were to assess visuospatial memory abilities in mild cognitive impairment (MCI), in order to verify whether these tasks might be valid as the standard cognitive test to differentiate […]
Effect of a computerized brain exercise program on cognitive performance in older adults
Miller, Karen J.,
Dye, Richelin V.,
Kim, Jeanne,
Jennings, Julia L.,
O'Toole, Elizabeth,
Wong, Julie,
Siddarth, Prabha
Objectives: Research indicates an association between stimulating mental activities and better memory performance as people age, but studies on computerized mental stimulation programs are limited. We explored whether computerized brain training exercises improved cognitive performance in older adults.; Methods: In local retirement communities, a convenience sample was randomized into an intervention group (N = 36), […]