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Cognitive training enhances pre-attentive neurophysiological responses in older adults ‘at risk’ of dementia


Mowszowski, Loren, Hermens, Daniel F., Diamond, Keri, Norrie, Louisa, Cockayne, Nicole, Ward, Philip B., Hickie, Ian B., Lewis, Simon J. G., Batchelor, Jennifer, Naismith, Sharon L.


Journal of Alzheimer's Disease, Volume: 41, No.: 4, Pages.: 1095-1108

Year of Publication



Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective:We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker of pre-attentive information processing, which in turn, is postulated to underpin higher-order cognitive processes. Methods: As part of a larger randomized controlled trial, forty ‘at risk’ (i.e., mild cognitive impairment or late-life depression) participants aged 51–79 years underwent neurophysiological, neuropsychological, and psychiatric assessments before and after a multi-faceted seven-week CT program or a ‘treatment-as-usual’ seven-week waitlist period. Results: The treatment group demonstrated significantly increased fronto-central MMN responses (p < 0.05), as well as improved phonemic verbal fluency (p < 0.05) and decreased self-rated memory difficulties (p < 0.05) following CT, in comparison to the waitlist control group. However, there were no significant correlations between enhanced MMN and cognitive/psychosocial outcomes. Conclusions: Results from this preliminary investigation indicate that CT is associated with enhanced neurophysiological mechanisms suggestive of improved pre-attentive processing, which may reflect alterations in underlying neurobiology. Further research is warranted to confirm these findings, to explicate whether CT is associated with restorative or compensatory neuroplastic processes and to determine whether MMN is a useful biomarker for treatment response. (PsycINFO Database Record (c) 2014 APA, all rights reserved). (journal abstract)


at risk populations, cognitive, cognitive impairment, cognitive processes, cognitive training, dementia, depression, geriatrics, late, latelife depression, life, major depression, mild cognitive impairment, mismatch negativity, neurophysiological, neurophysiology, neuropsychological, neuropsychology, training

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Non randomised controlled trial

Type of Outcomes




Type of Interventions

Non-pharmacological Treatment, Risk Factor Modification

Risk Factor Modifications

At risk population

Non-Pharmaceutical Interventions

Adult safeguarding and abuse detection/prevention