This database contains 125 studies, archived under the term: "study"
Click here to filter this large number of results.
Using acupressure and Montessori-based activities to decrease agitation for residents with dementia: a cross-over trial
Lin, Li-Chan,
Yang, Man-Hua,
Kao, Chieh-Chun,
Wu, Shiao-Chi,
Tang, Sai-Hung,
Lin, Jaung-Geng
Objectives: To explore the effectiveness of acupressure and Montessori-based activities in decreasing the agitated behaviors of residents with dementia.; Design: A double-blinded, randomized (two treatments and one control; three time periods) cross-over design was used.; Setting: Six special care units for residents with dementia in long-term care facilities in Taiwan were the sites for the […]
Training in dementia care: a cluster-randomized controlled trial of a training program for nursing home staff in Germany
Kuske, Bettina,
Luck, Tobias,
Hanns, Stephanie,
Matschinger, Herbert,
Angermeyer, Matthias C.,
Behrens, Johann,
Riedel-Heller, Steffi G.
Background: This study examines the effectiveness of a nursing home staff training program designed to improve the interaction between residents with dementia and their caregivers.; Methods: A three-arm cluster-randomized and controlled population of 96 caregivers and 210 residents was used. Caregivers of the intervention group (IG) received a three-month training program in dementia care. Data […]
Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease
Kountouras, Jannis,
Boziki, Marina,
Gavalas, Emmanuel,
Zavos, Christos,
Grigoriadis, Nikolaos,
Deretzi, Georgia,
Tzilves, Dimitrios,
Katsinelos, Panagiotis,
Tsolaki, Magda,
Chatzopoulos, Dimitrios,
Venizelos, Ioannis
Infectious agents have been proposed as potential causes of Alzheimer’s disease (AD). Recently, we documented a high prevalence of Helicobacter pylori (Hp) infection in patients with AD. We aim to access the effect of Hp eradication on the AD cognitive (MMSE: Mini Mental State Examination and CAMCOG: Cambridge Cognitive Examination for the Elderly) and functional […]
Trospium and cognition in patients with late onset Alzheimer disease
Objectives: Cholinesterase inhibitors for the treatment of Alzheimer’s Disease (AD) and antimuscarinic agents for the treatment of urge urinary incontinence (UUI) may reduce the potential effect of each other in the patients with both diseases. Trospium has a relatively low lipophilicity and low CNS penetration, and galantamine, a cholinesterase inhibitors, has also allosterically modulates nicotinic […]
Continuous positive airway pressure deepens sleep in patients with Alzheimer’s disease and obstructive sleep apnea
Cooke, Jana R.,
Ancoli-Israel, Sonia,
Liu, Lianqi,
Loredo, Jose S.,
Natarajan, Loki,
Palmer, Barton S.,
He, Feng,
Corey-Bloom, Jody
Objective: Patients with Alzheimer’s disease (AD) and obstructive sleep apnea (OSA) experience disrupted sleep. This study examined the effect of continuous positive airway pressure (CPAP) on sleep parameters in AD patients with OSA.; Methods: A randomized placebo-controlled trial of 3 weeks of therapeutic CPAP (tCPAP) vs. 3 weeks placebo CPAP (pCPAP) followed by 3 weeks […]
An exploratory cluster randomized controlled trial of group exercise on mobility and depression in care home residents
Brittle, Nicola,
Patel, Smitaa,
Wright, Christine,
Baral, Sabrina,
Versfeld, Pam,
Sackley, Catherine
Objective: To investigate the feasibility, acceptability and potential efficacy of group exercise for residents in care homes.; Design: Exploratory cluster randomized controlled trial.; Setting: Five randomly selected care homes in South Birmingham, UK.; Participants: Fifty-six care home residents (mean age 84.5, 71% female), 39 (70%) with cognitive impairments.; Intervention: Two homes (n = 28) were […]
An open-label study of memantine treatment in 3 subtypes of frontotemporal lobar degeneration
Boxer, Adam L.,
Lipton, Anne M.,
Womack, Kyle,
Merrilees, Jennifer,
Neuhaus, John,
Pavlic, Danijela,
Gandhi, Anisha,
Red, Dana,
Martin-Cook, Kristen,
Svetlik, Doris,
Miller, Bruce L.
There are currently no Food and Drug Administration-approved treatments for frontotemporal lobar degeneration (FTLD). The objectives of this study were to explore the tolerability of memantine treatment in FTLD and to monitor for possible effects on behavior, cognition, and function. Forty-three individuals who met clinical criteria for FTLD [21 with frontotemporal dementia (FTD), 13 with […]
Randomized controlled trial of atomoxetine for cognitive dysfunction in early Huntington disease
Beglinger, Leigh J.,
Adams, Williams H.,
Paulson, Henry,
Fiedorowicz, Jess G.,
Langbehn, Douglas R.,
Duff, Kevin,
Leserman, Anne,
Paulsen, Jane S.
Background: Cognitive symptoms are associated with functional disability in Huntington disease; yet, few controlled trials have examined cognitive treatments that could improve patient independence and quality of life. Atomoxetine is a norepinephrine reuptake inhibitor approved for treatment of attention-deficit/hyperactivity disorder.; Methods: Twenty participants with mild Huntington disease who complained of inattention were randomized to receive […]
Visual evoked potentials to pattern, motion and cognitive stimuli in Alzheimer’s disease
Kubová, Z.,
Kremlácek, J.,
Valis, M.,
Langrová, J.,
Szanyi, J.,
Vít, F.,
Kuba, M.
The aim of our study was to verify reported visual dysfunctions of patients with Alzheimer disease with the use of several variants of VEPs and visual ERPs and to learn whether these methods can be useful in diagnostics of AD. We tested 15 patients (6 women and 9 men, aged from 58 to 87) with […]
Errorless practice as a possible adjuvant to donepezil in Alzheimer’s disease
Rothi, Leslie J. Gonzalez,
Fuller, Renee,
Leon, Susan A.,
Kendall, Diane,
Moore, Anna,
Wu, Samuel S.,
Crosson, Bruce,
Heilman, Kenneth M.,
Nadeau, Stephen E.
Six individuals with probable Alzheimer’s disease (AD) participated in a phase 1 study employing a repeated measures, parallel baseline design testing the hypothesis that error-free experience during word production practice combined with an acetyl cholinesterase inhibitor would improve confrontation naming ability. While acetyl cholinesterase inhibitors are safe and delay cognition decline associated with AD, improvement […]