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Visual evoked potentials to pattern, motion and cognitive stimuli in Alzheimer’s disease


Kubová, Z., Kremlácek, J., Valis, M., Langrová, J., Szanyi, J., Vít, F., Kuba, M.


Documenta Ophthalmologica. Advances In Ophthalmology, Volume: 121, No.: 1, Pages.: 37-49

Year of Publication



The aim of our study was to verify reported visual dysfunctions of patients with Alzheimer disease with the use of several variants of VEPs and visual ERPs and to learn whether these methods can be useful in diagnostics of AD. We tested 15 patients (6 women and 9 men, aged from 58 to 87) with mild to moderate Alzheimer disease (12-23 points of Mini Mental State Examination) and 15 age, gender and education level matched controls. The examination consisted of VEPs to pattern-reversal and motion-onset stimulation (to translational and radial movement) and of visual ERPs recorded during an odd-ball test. The subjects were instructed to signalize target stimuli by pressing of a button, which enabled to evaluate also the reaction time. While pattern-reversal VEPs were comparable in patients and controls, there were significantly smaller N2 peak amplitudes of motion-onset VEPs in patients with AD (in particular in radial moving stimuli outside the central 20 deg of the visual field), which suggests a dysfunction of the motion-processing (magnocellular) system or the dorsal cortical stream. ERPs, having significantly longer latencies in patients than in controls, distinguished well both groups. However, the individual AD diagnostics based on ERPs seems to be limited by rather high inter-individual variability of the ERP latencies. The ERPs might, however, be useful in disease progress and therapy effect estimation. Electrophysiological parameters did not correlate with neuropsychological ADAS cog test (Alzheimer Disease Assessment Scale–cognitive part).;

Bibtex Citation

@article{Kubov__2010, doi = {10.1007/s10633-010-9230-5}, url = {}, year = 2010, month = {jun}, publisher = {Springer Science $mathplus$ Business Media}, volume = {121}, number = {1}, pages = {37--49}, author = {Z. Kubov{'{a}} and J. Kreml{'{a}}{v{c}}ek and M. Vali{v{s}} and J. Langrov{'{a}} and J. Szanyi and F. V{'{i}}t and M. Kuba}, title = {Visual evoked potentials to pattern, motion and cognitive stimuli in Alzheimer's disease}, journal = {Documenta Ophthalmologica} }


aged, aged, 80 and over, alzheimer disease, and, cognition, erps, evoked potentials, evoked potentials visual, female, humans, male, methods, middle aged, motion perception, photic stimulation, physiopathology, psychological tests, psychology, reaction time, severity of illness index, veps, visual

Countries of Study

Czech Republic

Types of Dementia

Alzheimer’s Disease

Types of Study

Cohort Study, Epidemiological

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets