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Continuous positive airway pressure deepens sleep in patients with Alzheimer’s disease and obstructive sleep apnea


Cooke, Jana R., Ancoli-Israel, Sonia, Liu, Lianqi, Loredo, Jose S., Natarajan, Loki, Palmer, Barton S., He, Feng, Corey-Bloom, Jody


Sleep Medicine, Volume: 10, No.: 10, Pages.: 1101-1106

Year of Publication



Objective: Patients with Alzheimer’s disease (AD) and obstructive sleep apnea (OSA) experience disrupted sleep. This study examined the effect of continuous positive airway pressure (CPAP) on sleep parameters in AD patients with OSA.; Methods: A randomized placebo-controlled trial of 3 weeks of therapeutic CPAP (tCPAP) vs. 3 weeks placebo CPAP (pCPAP) followed by 3 weeks tCPAP in patients with AD and OSA. Polysomnography data from screening after one night and after 3 weeks of treatment were analyzed. Records were scored for percent of each sleep stage, total sleep time (TST), sleep efficiency (SE), sleep period (SP), time in bed (TIB), sleep onset (SO), wake time after sleep onset (WASO), and arousals. A randomized design comparing one night of pCPAP to tCPAP and a paired analysis combining 3 weeks of tCPAP were performed.; Results: Fifty-two participants (mean age=77.8 years, SD=7.3) with AD and OSA were included. After one treatment night, the tCPAP group had significantly less % Stage 1 (p=0.04) and more % Stage 2 sleep (p=0.02) when compared to the pCPAP group. In the paired analysis, 3 weeks of tCPAP resulted in significant decreases in WASO (p=0.005), % Stage 1 (p=0.001), arousals (p=0.005), and an increase in % Stage 3 (p=0.006).; Conclusion: In mild to moderate AD patients with OSA, the use of tCPAP resulted in deeper sleep after just one night, with improvements maintained for 3 weeks.;

Bibtex Citation

@article{Cooke_2009, doi = {10.1016/j.sleep.2008.12.016}, url = {}, year = 2009, month = {dec}, publisher = {Elsevier {BV}}, volume = {10}, number = {10}, pages = {1101--1106}, author = {Jana R. Cooke and Sonia Ancoli-Israel and Lianqi Liu and Jose S. Loredo and Loki Natarajan and Barton S. Palmer and Feng He and Jody Corey-Bloom}, title = {Continuous positive airway pressure deepens sleep in patients with Alzheimer's disease and obstructive sleep apnea}, journal = {Sleep Medicine} }


aged, aged, 80 and over, alzheimer disease, apnea, arousal, circadian rhythm, comorbidity, continuous positive airway pressure, female, humans, male, obstructive, osa, physiology, physiopathology, polysomnography, sleep, sleep apnea obstructive, sleep rem, sleep stages, therapy, time factors, treatment outcome

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Treatment/prevention of co-morbidities or additional risks