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This database contains 193 studies, archived under the term: "results"

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A subtest of the MMSE as a valid test of episodic memory? Comparison with the Free and Cued Reminding Test
Background/aims: Episodic memory impairment is known to be the core of Alzheimer’s disease (AD) dementia syndrome and one of the earliest domains to decline. However, episodic memory tests are long and expensive.; Methods: In a sample of the French Three-City Study (n = 1,516), we aimed at validating a subtest of the Mini-Mental State Examination […]

Trazodone improves sleep parameters in Alzheimer disease patients: A randomized, double-blind, and placebo-controlled study
Objectives: There are no randomized clinical trials regarding efficacy of trazodone in the treatment of sleep disturbances (SD) in patients with Alzheimer disease (AD). We tested the efficacy and safety of trazodone to treat SD in patients with AD. Design: We conducted a double-blind, randomized and controlled trial during periods of 7–9 days at baseline […]

Effect of TTP488 in patients with mild to moderate Alzheimer’s disease
Background: TTP488, an antagonist at the Receptor for Advanced Glycation End products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer’s disease (AD). A previous report describes decreased decline in ADAS-cog (delta = 3.1, p = 0.008 at 18 months, ANCOVA with multiple imputation), relative to placebo, following a 5 mg/day dose of TTP488. Acute, reversible cognitive […]

Validation of Alzheimer’s disease CSF and plasma biological markers: the multicentre reliability study of the pilot European Alzheimer’s Disease Neuroimaging Initiative (E-ADNI)
Background: Alzheimer’s Disease Neuroimaging Initiatives (“ADNI”) aim to validate neuroimaging and biochemical markers of Alzheimer’s disease (AD). Data of the pilot European-ADNI (E-ADNI) biological marker programme of cerebrospinal fluid (CSF) and plasma candidate biomarkers are reported.; Methods: Six academic EADC centres recruited 49 subjects (healthy controls, subjects with mild cognitive impairment (MCI) and AD). We […]

The burden of spousal caregiving: a preliminary psychometric evaluation of the German version of the Zarit burden interview
Objectives: Despite a rapid increase in studies dealing with dementia caregivers in Europe, a valid German version of the most widely used measurement of caregiver burden (Zarit Burden Interview) has not yet been published. The purpose of this study is to evaluate the psychometric properties of the German Zarit Burden Interview (G-ZBI).; Method: Twenty-eight community-dwelling […]

An evaluation of the effectiveness of a case-specific approach to challenging behaviour associated with dementia
Objectives: Treatment of challenging behaviour in dementia using standardized psychopharmacological or psychosocial approaches remains problematical. A case-specific approach was trialled in this study, based on extensive evidence that each case is different in aetiology, the effects of the behaviour on others and what interventions are possible given the available resources.; Method: Forty-four consecutive referrals for […]

Olive oil and cognition: results from the three-city study
Background: Olive oil is a major component of the Mediterranean diet suggested to be beneficial to counteract Alzheimer’s disease.; Aim Of the Study: Our objective was to examine the association between olive oil use, cognitive deficit and cognitive decline in a large elderly population.; Methods: We followed 6,947 subjects with a brief baseline food frequency […]

Predicting decline in mild cognitive impairment: A prospective cognitive study
Objective: The primary aim of this study was to identify cognitive tests that differentiate between persons with mild cognitive impairment (MCI) who later develop cognitive decline and those who remain stable. Method: This study used a prospective longitudinal design. One hundred twenty-two older adults with single-domain or multiple-domain amnestic MCI were recruited from memory clinics. […]

Cognitive function and common mental disorders in older people with vascular and non-vascular disorders: a national survey
Objective: Vascular disorders are important potential causes of cognitive impairment and common mental disorders but their specificity as risk factors has yet to be clarified. The objectives of this analysis were to compare vascular and non-vascular health problems with respect to their associations with cognitive function and common mental disorder.; Method: An analysis was carried […]

A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease
Purpose: Mild cognitive deficits associated with HIV disease can affect activities of daily living, so interventions that reduce them may have a long-term effect on quality of life. We evaluated the feasibility of a cognitive stimulation program (CSP) to improve neuropsychological test performance in HIV disease.; Methods: Sixty volunteers (30 HIV-infected) participated. The primary outcome […]

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