This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease


Becker, James T., Dew, Mary Amanda, Aizenstein, Howard J., Lopez, Oscar L., Morrow, Lisa, Saxton, Judith, Tárraga, Lluís


Disability And Rehabilitation, Volume: 34, No.: 21, Pages.: 1848-1852

Year of Publication



Purpose: Mild cognitive deficits associated with HIV disease can affect activities of daily living, so interventions that reduce them may have a long-term effect on quality of life. We evaluated the feasibility of a cognitive stimulation program (CSP) to improve neuropsychological test performance in HIV disease.; Methods: Sixty volunteers (30 HIV-infected) participated. The primary outcome was the change in neuropsychological test performance as indexed by the Global Impairment Rating; secondary outcomes included mood (Brief Symptom Inventory subscales) and quality of life rating (Medical Outcomes Survey-HIV) scales.; Results: Fifty-two participants completed all 24 weeks of the study, and 54% of the participants in the CSP group successfully used the system via internet access from their home or other location. There was a significant interaction between usage and study visit such that the participants who used the program most frequently showed significantly greater improvements in cognitive functioning (F(3, 46.4 = 3.26, p = 0.030); none of the secondary outcomes were affected by the dose of CSP.; Conclusions: We found it possible to complete an internet-based CSP in HIV-infected individuals; ease of internet access was a key component for success. Participants who used the program most showed improvements in cognitive function over the 24-week period, suggesting that a larger clinical trial of CSP may be warranted.;

Bibtex Citation

@article{Becker_2012, doi = {10.3109/09638288.2012.667188}, url = {}, year = 2012, month = {mar}, publisher = {Informa {UK} Limited}, volume = {34}, number = {21}, pages = {1848--1852}, author = {James T. Becker and Mary Amanda Dew and Howard J. Aizenstein and Oscar L. Lopez and Lisa Morrow and Judith Saxton and Llu{'{i}}s T{'{a}}rraga}, title = {A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in {HIV} disease}, journal = {Disability and Rehabilitation} }


activities of daily living, adult, aged, cognitive therapy, complications, feasibility studies, female, hiv infections, humans, internet, male, methods, middle aged, mild cognitive impairment, neuropsychological tests, pilot projects, psychiatric status rating scales, psychology, quality of life, statistics & numerical data, therapy, treatment outcome

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Cohort Study

Type of Outcomes


Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Adult safeguarding and abuse detection/prevention