This database contains 1433 studies, archived under the term: ""
Click here to filter this large number of results.
Impact of ambient bright light on agitation in dementia
Barrick, Ann Louise,
Sloane, Philip D.,
Williams, Christianna S.,
Mitchell, C. Madeline,
Connell, Bettye Rose,
Wood, Wendy,
Hickman, Susan E.,
Preisser, John S.,
Zimmerman, Sheryl
Objective: To evaluate the effect of ambient bright light therapy (BLT) on agitation among institutionalized persons with dementia. Methods: High intensity, low glare ambient lighting was installed in activity and dining areas of a state psychiatric hospital unit in North Carolina and a dementia-specific residential care facility in Oregon. The study employed a cluster-unit crossover […]
Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial)
Ballard, Clive,
Brown, Richard,
Fossey, Jane,
Douglas, Simon,
Bradley, Paul,
Hancock, Judith,
James, Ian A.,
Juszczak, Edmund,
Bentham, Peter,
Burns, Alistair,
Lindesay, James,
Jacoby, Robin,
O'Brien, John,
Bullock, Roger,
Johnson, Tony,
Holmes, Clive,
Howard, Robert
Background: Good practice guidelines state that a psychological intervention should usually precede pharmacotherapy, but there are no data evaluating the feasibility of psychological interventions used in this way. Methods: At the first stage of a randomized blinded placebo-controlled trial, 318 patients with Alzheimer disease (AD) with clinically significant agitated behavior were treated in an open […]
Effects of a controlled trial of aerobic exercise for mild cognitive impairment: A controlled trial
Baker, Laura D.,
Frank, Laura L.,
Foster-Schubert, Karen,
Green, Pattie S.,
Wilkinson, Charles W.,
McTiernan, Anne,
Plymate, Stephen R.,
Fishel, Mark A.,
Watson, G. Stennis,
Cholerton, Brenna A.,
Dunca, Glen E.,
Mehta, Pankaj D.,
Craft, Suzanne
Objectives: To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response. Design: Six-month, randomized, controlled, clinical trial. Setting: Veterans Affairs Puget Sound Health Care System clinical research unit. Participants: Thirty-three […]
Efectos del entrenamiento en estrategias de regulación emocional en el bienestar de cuidadores de enfermos de Alzheimer. = Effects of training in emotional regulation strategies on the well-being of carers of Alzheimer patients
Arritxabal, Igone Etxeberria,
Soler, Álvaro García,
Da Silva, Ainhoa Iglesias,
Artola, Elena Urdaneta,
González, Idoia Lorea,
Veiga, Pura Díaz,
Yanguas Lezaun, José Javier
Introduction; The present research shows the results of a psychoeducational Intervention programme centered on the regulation of the emotion among Alzheimer patients’ caregivers. Materials and methods: 52 informal caregivers of Alzheimer’s patients participated. These caregivers were distributed into two groups: the experimental group (n = 20) and the control group (n = 32). All the […]
Efficacy and safety of cerebrolysin in moderate to moderately severe Alzheimer’s disease: Results of a randomized, double‐blind, controlled trial investigating three dosages of cerebrolysin
Alvarez, X. A.,
Cacabelos, R.,
Sampedro, C.,
Aleixandre, M.,
Linares, C.,
Granizo, E.,
Doppler, E.,
Moessler, H.
Background: Cerebrolysin is a neuropeptide preparation mimicking the effects of neurotrophic factors. This subgroup analysis assessed safety and efficacy of Cerebrolysin in patients with moderate to moderately severe Alzheimer’s disease (AD) (ITT data set: N = 133; MMSE: 14–20) included in a dose‐finding study (ITT data set: N = 251; MMSE: 14–25). Results of the […]
Randomized controlled trial of a Healthy Brain Ageing Cognitive Training program: Effects on memory, mood, and sleep
Diamond, Keri,
Mowszowski, Loren,
Cockayne, Nicole,
Norrie, Louisa,
Paradise, Matthew,
Hermens, Daniel F.,
Lewis, Simon J. G.,
Hickie, Ian B.,
Naismith, Sharon L.
Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those ‘at risk’ of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults ‘at […]
Mild cognitive impairment disease treated with electroacupuncture: a multi-center randomized controlled trial
Zhao, Ling,
Zhang, Fu-Wen,
Zhang, Hong,
Zhao, Yu,
Zhou, Bo,
Chen, Wei-Yin,
Zhu, Man-Jia
Objective: To verify the clinical efficacy on mild cognitive impairment (MCI) treated with electroacupuncture (EA) intervention based on the principle as “promoting the circulation of the Governor Vessel and regulating the marrow” and plan to provide the A-grade evidence of the evidence-based medicine for the clinical treatment of this disease with acupuncture and moxibustion.; Methods: […]
Treatment with Huperzine A improves cognition in vascular dementia patients
Xu, Zhi-Qiang,
Liang, Xiao-Min,
Juan, Wu,
Zhang, Yuan-Feng,
Zhu, Chun-Xia,
Jiang, Xiao-Jiang
Unlabelled: In the present study, we tested the efficacy and safety of Huperzine A in treatment of mild to moderate vascular dementia (VaD). This was a randomized, double-blinded, placebo-controlled study with 78 patients with mild to moderate VaD. The participants were randomized to receive either vitamin C (100-mg bid) as placebo (n = 39) or […]