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Treatment with Huperzine A improves cognition in vascular dementia patients


Xu, Zhi-Qiang, Liang, Xiao-Min, Juan, Wu, Zhang, Yuan-Feng, Zhu, Chun-Xia, Jiang, Xiao-Jiang


Cell Biochemistry And Biophysics, Volume: 62, No.: 1, Pages.: 55-58

Year of Publication



Unlabelled: In the present study, we tested the efficacy and safety of Huperzine A in treatment of mild to moderate vascular dementia (VaD). This was a randomized, double-blinded, placebo-controlled study with 78 patients with mild to moderate VaD. The participants were randomized to receive either vitamin C (100-mg bid) as placebo (n = 39) or Huperzine A (0.1-mg bid) (n = 39) for 12 consecutive weeks. The mini-mental state examination (MMSE), clinical dementia rating (CDR), and activities of daily living (ADL) scores were used for the assessment of cognition. The assessments were made prior to treatment, and 4, 8, and 12 weeks of the treatment. The adverse effects of the treatment were also recorded. After 12 weeks of treatment, the MMSE, CDR, and ADL scores significantly improved in the Huperzine A group (P < 0.01 for all comparisons), whereas the placebo group did not show any such improvement (P > 0.05 for all comparisons). No serious adverse events were recorded during the treatment.; Conclusion: Huperzine A can significantly improve the cognitive function in patients with mild to moderate vascular dementia. Further, the medicament is safe.;

Bibtex Citation

@article{Xu_2011, doi = {10.1007/s12013-011-9258-5}, url = {}, year = 2011, month = {aug}, publisher = {Springer Science $mathplus$ Business Media}, volume = {62}, number = {1}, pages = {55--58}, author = {Zhi-Qiang Xu and Xiao-Min Liang and Juan-Wu and Yuan-Feng Zhang and Chun-Xia Zhu and Xiao-Jiang Jiang}, title = {Treatment with Huperzine A Improves Cognition in Vascular Dementia Patients}, journal = {Cell Biochem Biophys} }


a, activities of daily living, adverse, aged, alkaloids, ascorbic acid, c, cognition, dementia vascular, doubleblind method, drug administration schedule, drug effects, drug therapy, events, female, humans, huperzine, male, middle aged, neuroprotective agents, pharmacology, placebo effect, sesquiterpenes, severity of illness index, therapeutic use, vitamin

Countries of Study


Types of Dementia

Vascular Dementia

Types of Study

Randomised Controlled Trial

Type of Outcomes

ADLs/IADLs, Cognition, Other

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements, Other