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Randomized controlled trial of a Healthy Brain Ageing Cognitive Training program: Effects on memory, mood, and sleep


Diamond, Keri, Mowszowski, Loren, Cockayne, Nicole, Norrie, Louisa, Paradise, Matthew, Hermens, Daniel F., Lewis, Simon J. G., Hickie, Ian B., Naismith, Sharon L.


Journal of Alzheimer's Disease, Volume: 44, No.: 4, Pages.: 1181-1191

Year of Publication



Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those ‘at risk’ of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults ‘at risk’ of dementia. Methods: Using a single-blinded design, 64 participants (mean age = 66.5 years, SD = 8.6) were randomized to an immediate treatment (HBA-CT) or treatment-as-usual control arm. The HBA-CT intervention was conducted twice-weekly for seven weeks and comprised group-based psychoeducation about cognitive strategies and modifiable lifestyle factors pertaining to healthy brain ageing, and computerized cognitive training. Results: In comparison to the treatment-as-usual control arm, the HBA-CT program was associated with improvements in verbal memory (p = 0.03), self-reported memory (p = 0.03), mood (p = 0.01), and sleep (p = 0.01). While the improvements in memory (p = 0.03) and sleep (p = 0.02) remained after controlling for improvements in mood, only a trend in verbal memory improvement was apparent after controlling for sleep. Conclusion: The HBA-CT program improves cognitive, mood, and sleep functions in older adults ‘at risk’ of dementia, and therefore offers promise as a secondary prevention strategy. (PsycINFO Database Record (c) 2015 APA, all rights reserved). (journal abstract)


andor, at risk populations, based, brain, cognitive, cognitive impairment, cognitive techniques, dementia, depression, depression emotion, emotional states, group, impairment, memory, mental health programs, mild, mild cognitive impairment, neuropsychology, psychoeducation, sleep, sleep disorders, treatment effectiveness evaluation

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Randomised Controlled Trial

Type of Outcomes

Behaviour, Cognition, Other



Type of Interventions

Non-pharmacological Treatment, Risk Factor Modification

Risk Factor Modifications

At risk population

Non-Pharmaceutical Interventions

Behavioural Therapies