This database contains 82 studies, archived under the term: "Adult safeguarding and abuse detection/prevention"
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Semantic memory training in Alzheimer’s disease
The purpose of this study was to assess the effects of semantic stimulation of Alzheimer’s patients on semantic memory comparatively to psychological support. We conducted semantic training with two target categories (musical instruments and human actions), because these concepts were massively failed in previous data collected in Alzheimer’s disease. Ten patients (57-78 year old, MMSE […]
Can a memory club help maintain cognitive function? A pilot investigation
Fritsch, Thomas,
McClendon, McKee J.,
Wallendal, Maggie S.,
Smyth, Kathleen A.,
Geldmacher, David S.,
Hyde, Trevor F.,
Leo, Gary J.
In a pilot investigation we evaluated the impact of a structured early memory loss (EML) program intervention in a longitudinal (repeated measures) study of 55 persons with mild cognitive impairment or mild dementia. At four test sites we examined whether participation in the club—which sought to stimulate mental activity and social interaction, provide opportunities for […]
Effects of cognitive training on gray matter volumes in memory clinic patients with subjective memory impairment
Engvig, Andreas,
Fjell, Anders M.,
Westlye, Lars T.,
Skaane, Nina V.,
Dale, Anders M.,
Holland, Dominic,
Due-Tønnessen, Paulina,
Sundseth, Øyvind,
Walhovd, Kristine B.
Subjective memory impairment (SMI) is a common risk factor for Alzheimer’s disease, with few established options for treatment. Here we investigate the effects of two months episodic memory training on regional brain atrophy in 19 memory clinic patients with SMI. We used a sensitive longitudinal magnetic resonance imaging protocol and compared the patients with 42 […]
A complex multimodal activity intervention to reduce the risk of dementia in mild cognitive impairment–ThinkingFit: Pilot and feasibility study for a randomized controlled trial
Dannhauser, Thomas M.,
Cleverley, Martin,
Whitfield, Tim J.,
Fletcher, Ben,
Stevens, Tim,
Walker, Zuzana
Background: Dementia affects 35 million people worldwide and is currently incurable. Many cases may be preventable because regular participation in physical, mental and social leisure activities during middle age is associated with up to 47% dementia risk reduction. However, the majority of middle-aged adults are not active enough. MCI is therefore a clear target for […]
Effect of cognitive training on the expression of brain-derived neurotrophic factor in lymphocytes of mild cognitive impairment patients
Casoli, Tiziana,
Giuli, Cinzia,
Balietti, Marta,
Giorgetti, Belinda,
Solazzi, Moreno,
Fattoretti, Patrizia
To identify biomarkers associated with cognitive stimulation of mild cognitive impairment (MCI) patients, we performed quantitative real-time reverse transcriptase polymerase chain reaction for brain-derived neurotrophic factor (BDNF) mRNA in peripheral lymphocytes of MCI and healthy subjects undergoing a multi-component cognitive training (CT) program. CT determined a significant decrease of BDNF mRNA levels in MCI (fold […]
A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease
Becker, James T.,
Dew, Mary Amanda,
Aizenstein, Howard J.,
Lopez, Oscar L.,
Morrow, Lisa,
Saxton, Judith,
Tárraga, Lluís
Purpose: Mild cognitive deficits associated with HIV disease can affect activities of daily living, so interventions that reduce them may have a long-term effect on quality of life. We evaluated the feasibility of a cognitive stimulation program (CSP) to improve neuropsychological test performance in HIV disease.; Methods: Sixty volunteers (30 HIV-infected) participated. The primary outcome […]