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Effect of cognitive training on the expression of brain-derived neurotrophic factor in lymphocytes of mild cognitive impairment patients


Casoli, Tiziana, Giuli, Cinzia, Balietti, Marta, Giorgetti, Belinda, Solazzi, Moreno, Fattoretti, Patrizia


Rejuvenation Research, Volume: 17, No.: 2, Pages.: 235-238

Year of Publication



To identify biomarkers associated with cognitive stimulation of mild cognitive impairment (MCI) patients, we performed quantitative real-time reverse transcriptase polymerase chain reaction for brain-derived neurotrophic factor (BDNF) mRNA in peripheral lymphocytes of MCI and healthy subjects undergoing a multi-component cognitive training (CT) program. CT determined a significant decrease of BDNF mRNA levels in MCI (fold change=0.31) as compared to healthy subjects (fold change=0.86). It has been reported that in MCI there is an increase of BDNF serum levels, and our findings could indicate a positive effect of CT in restoring pre-disease levels of expression.;

Bibtex Citation

@article{Casoli_2014, doi = {10.1089/rej.2013.1516}, url = {}, year = 2014, month = {apr}, publisher = {Mary Ann Liebert Inc}, volume = {17}, number = {2}, pages = {235--238}, author = {Tiziana Casoli and Cinzia Giuli and Marta Balietti and Belinda Giorgetti and Moreno Solazzi and Patrizia Fattoretti}, title = {Effect of Cognitive Training on the Expression of Brain-Derived Neurotrophic Factor in Lymphocytes of Mild Cognitive Impairment Patients}, journal = {Rejuvenation Research} }


aged, blood, cognition, humans, lymphocytes, metabolism, mild cognitive impairment, neuropsychological tests, physiopathology

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Non randomised controlled trial

Type of Outcomes


Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Adult safeguarding and abuse detection/prevention