This database contains 32 studies, archived under the term: "young adult"
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The synergistic effect of acupuncture and computer-based cognitive training on post-stroke cognitive dysfunction: a study protocol for a randomized controlled trial of 2 × 2 factorial design
Yang, Shanli,
Ye, Haicheng,
Huang, Jia,
Tao, Jing,
Jiang, Cai,
Lin, Zhicheng,
Zheng, Guohua,
Chen, Lidian
Background: Stroke is one of the most common causes of cognitive impairment. Up to 75% of stroke survivors may be considered to have cognitive impairment, which severely limit individual autonomy for successful reintegration into family, work and social life. The clinical efficacy of acupuncture with Baihui (DU20) and Shenting (DU24) in stroke and post-stroke cognitive […]
Clinical stabilisation in neurodegenerative diseases: clinical study in phase II
Introduction: Neurodegenerative disorders, such as Parkinson’s disease (PD), Alzheimer’s disease (AD) and multiple sclerosis (MS), are progressive pathological conditions in which current treatments have not proved to be effective at curbing their progress (clinical stabilisation). Although they have very different clinical characteristics, they share the same pathophysiological mechanisms of progression. We developed a compound designed […]
Randomized controlled trial of atomoxetine for cognitive dysfunction in early Huntington disease
Beglinger, Leigh J.,
Adams, Williams H.,
Paulson, Henry,
Fiedorowicz, Jess G.,
Langbehn, Douglas R.,
Duff, Kevin,
Leserman, Anne,
Paulsen, Jane S.
Background: Cognitive symptoms are associated with functional disability in Huntington disease; yet, few controlled trials have examined cognitive treatments that could improve patient independence and quality of life. Atomoxetine is a norepinephrine reuptake inhibitor approved for treatment of attention-deficit/hyperactivity disorder.; Methods: Twenty participants with mild Huntington disease who complained of inattention were randomized to receive […]
Detecting frontotemporal dysfunction in ALS: utility of the ALS Cognitive Behavioral Screen (ALS-CBS)
Woolley, Susan C.,
York, Michele K.,
Moore, Dan H.,
Strutt, Adriana M.,
Murphy, Jennifer,
Schulz, Paul E.,
Katz, Jonathan S.
Up to half of patients with ALS develop cognitive impairment during the course of the illness. Despite this, there is no simple tool for screening patients in the clinical setting. This study examines the sensitivity, specificity and accuracy of the ALS Cognitive Behavioral Screen (ALS-CBS). We administered the measure to 112 ALS patients, including 31 […]
Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study
Teipel, Stefan J.,
Reuter, Sigrid,
Stieltjes, Bram,
Acosta-Cabronero, Julio,
Ernemann, Ulrike,
Fellgiebel, Andreas,
Filippi, Massimo,
Frisoni, Giovanni,
Hentschel, Frank,
Jessen, Frank,
Klöppel, Stefan,
Meindl, Thomas,
Pouwels, Petra J.W.,
Hauenstein, Karl-Heinz,
Hampel, Harald
Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans […]
Psychometric evaluation of the Swedish version of the Person-Centered Care Assessment Tool (P-CAT)
Background: Person-centered care is a multidimensional concept describing good care, especially within aged care and care for people with dementia. Research studies evaluating person-centered care interventions seldom use direct measurement of levels of person-centeredness. Existing scales that measure person-centeredness need further testing. This study evaluated the psychometric properties of the Swedish version of the Person-Centered […]