Drumond Marra, Hellen Livia, Myczkowski, Martin Luiz, Maia Memória, Cláudia, Arnaut, Débora, Leite Ribeiro, Philip, Sardinha Mansur, Carlos Gustavo, Lancelote Alberto, Rodrigo, Boura Bellini, Bianca, Alves Fernandes da Silva, Adriano, Tortella, Gabriel, Ciampi de Andrade, Daniel, Teixeira, Manoel Jacobsen, Forlenza, Orestes Vicente, Marcolin, Marco Antonio

Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with […]

Cotelli, Maria, Manentil, Rosa, Rosini, Sandra, Brambilla, Michela, Zanetti, Orazio, Miniussi, Carlo

Recent studies have reported enhanced performance on specific cognitive tasks in patients with several types of neurological disease, after receiving non invasive brain stimulation (BS), i.e., repetitive Transcranial Magnetic Stimulation (rTMS) or transcranial Direct Current Stimulation (tDCS) to specific cortical areas. In addition, persistent beneficial effects of off-line rTMS on sentence comprehension in Alzheimer disease […]

Flöel, Agnes, Suttorp, Wiebke, Kohl, Oliver, Kürten, Julia, Lohmann, Hubertus, Breitenstein, Caterina, Knecht, Stefan

Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean age 62.1 years) right-handed […]

Ahmed, Mohamed A., Darwish, Esam S., Khedr, Eman M., El Serogy, Yasser M., Ali, Anwer M.

The aim of the study was to compare the long-term efficacy of high versus low frequency repetitive transcranial magnetic stimulation (rTMS), applied bilaterally over the dorsolateral prefrontal cortex (DLPFC), on cognitive function and cortical excitability of patients with Alzheimer’s disease (AD). Forty-five AD patients were randomly classified into three groups. The first two groups received […]

Cotelli, Maria, Calabria, Marco, Manenti, Rosa, Rosini, Sandra, Zanetti, Orazio, Cappa, Stefano F., Miniussi, Carlo

Objectives: Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible treatment for the cognitive deficits associated with Alzheimer disease (AD). The aim of this study was to assess the long-term effects, on cognitive performance, of rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) in AD patients.; Methods: Ten AD patients were randomly […]

Takahashi, Sho, Mizukami, Katsuyoshi, Yasuno, Fumihiko, Asada, Takashi

Background: Dementia with Lewy bodies (DLB) is a common type of dementia. It is difficult to make an initial diagnosis of DLB because of a variety of early symptoms, including psychosis-like and depressive states. In this study, we examined the characteristic depressive symptoms of the prestage of DLB and the efficacy and safety of somatotherapy […]

Suemoto, Claudia Kimie, Apolinario, Daniel, Nakamura-Palacios, Ester Miyuki, Lopes, Leonardo, Paraizo Leite, Renata Elaine, Sales, Manuela Castro, Nitrini, Ricardo, Brucki, Sonia Maria, Morillo, Lilian Shafirovitz, Magaldi, Regina Miksian, Fregni, Felipe

Background: Apathy is the most common neuropsychiatric symptom in Alzheimer’s disease (AD) and it is associated with changes in prefrontal neural circuits involved with generation of voluntary actions. To date no effective treatment for apathy has been demonstrated. Objective: We aimed to investigate the effects and safety of repetitive transcranial direct current stimulation (tDCS) on […]

Rabey, Jose M., Dobronevsky, Evgenia, Aichenbaum, Sergio, Gonen, Ofer, Marton, Revital Gendelman, Khaigrekht, Michael

Cortical excitability can be modulated using repetitive transcranial magnetic stimulation (rTMS). Previously, we showed that rTMS combined with cognitive training (rTMS-COG) has positive results in Alzheimer’s disease (AD). The goal of this randomized double-blind, controlled study was to examine the safety and efficacy of rTMS-COG in AD. Fifteen AD patients received 1-h daily rTMS-COG or […]

Martorana, Alessandro, Di Lorenzo, Francesco, Esposito, Zaira, Lo Giudice, Temistocle, Bernardi, Giorgio, Caltagirone, Carlo, Koch, Giacomo

Dopamine is a neurotransmitter involved in several brain functions ranging from emotions control, movement organization to memory formation. It is also involved in the regulation of mechanisms of synaptic plasticity. However, its role in Alzheimer’s disease (AD) pathogenesis is still puzzling. Several recent line of research instead indicates a clear role for dopamine in both […]