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Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study


Drumond Marra, Hellen Livia, Myczkowski, Martin Luiz, Maia Memória, Cláudia, Arnaut, Débora, Leite Ribeiro, Philip, Sardinha Mansur, Carlos Gustavo, Lancelote Alberto, Rodrigo, Boura Bellini, Bianca, Alves Fernandes da Silva, Adriano, Tortella, Gabriel, Ciampi de Andrade, Daniel, Teixeira, Manoel Jacobsen, Forlenza, Orestes Vicente, Marcolin, Marco Antonio


Behavioural Neurology, Volume: 2015, Pages.: 287843-287843

Year of Publication



Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with MCI. We conducted a double-blinded randomized sham-controlled trial using rTMS over the left dorsolateral prefrontal cortex (DLPFC). Thirty-four elderly outpatients meeting Petersen’s MCI criteria were randomly assigned to receive 10 sessions of either active TMS or sham, 10 Hz rTMS at 110% of motor threshold, 2,000 pulses per session. Neuropsychological assessment at baseline, after the last session (10th) and at one-month follow-up, was applied. ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction (p = 0.05), favoring the active group. The improvement was kept after one month. Other neuropsychological tests were heterogeneous. rTMS at 10 Hz enhanced everyday memory in elderly with MCI after 10 sessions. These findings suggest that rTMS might be effective as a therapy for MCI and probably a tool to delay deterioration.;

Bibtex Citation

@article{Drumond_Marra_2015, doi = {10.1155/2015/287843}, url = {}, year = 2015, publisher = {Hindawi Publishing Corporation}, volume = {2015}, pages = {1--13}, author = {Hellen Livia Drumond Marra and Martin Luiz Myczkowski and Cl{'{a}}udia Maia Mem{'{o}}ria and D{'{e}}bora Arnaut and Philip Leite Ribeiro and Carlos Gustavo Sardinha Mansur and Rodrigo Lancelote Alberto and Bianca Boura Bellini and Adriano Alves Fernandes da Silva and Gabriel Tortella and Daniel Ciampi de Andrade and Manoel Jacobsen Teixeira and Orestes Vicente Forlenza and Marco Antonio Marcolin}, title = {Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study}, journal = {Behavioural Neurology} }


aged, female, humans, magnetic, male, memory, methods, middle aged, mild cognitive impairment, motor cortex, neuropsychological tests, physiology, physiopathology, prefrontal cortex, stimulation, therapy, transcranial, transcranial magnetic stimulation, treatment outcome

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Randomised Controlled Trial

Type of Outcomes



Hospital Outpatient Care

Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions