This database contains 74 studies, archived under the term: "pathology"
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Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease
Zerr, I.,
Kallenberg, K.,
Summers, D. M.,
Romero, C.,
Taratuto, A.,
Heinemann, U.,
Breithaupt, M.,
Varges, D.,
Meissner, B.,
Ladogana, A.,
Schuur, M.,
Haik, S.,
Collins, S. J.,
Jansen, G. H.,
Stokin, G. B.,
Pimentel, J.,
Hewer, E.,
Collie, D.,
Smith, P.,
Roberts, H.,
Brandel, J. P.,
van Duijn, C.,
Pocchiari, M.,
Begue, C.,
Cras, P.,
Will, R. G.,
Sanchez-Juan, P.
Several molecular subtypes of sporadic Creutzfeldt-Jakob disease have been identified and electroencephalogram and cerebrospinal fluid biomarkers have been reported to support clinical diagnosis but with variable utility according to subtype. In recent years, a series of publications have demonstrated a potentially important role for magnetic resonance imaging in the pre-mortem diagnosis of sporadic Creutzfeldt-Jakob disease. […]
Comparing registration methods for mapping brain change using tensor-based morphometry
Measures of brain changes can be computed from sequential MRI scans, providing valuable information on disease progression for neuroscientific studies and clinical trials. Tensor-based morphometry (TBM) creates maps of these brain changes, visualizing the 3D profile and rates of tissue growth or atrophy. In this paper, we examine the power of different nonrigid registration models […]
Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial
Williamson, Jeff D.,
Launer, Lenore J.,
Bryan, R. Nick,
Coker, Laura H.,
Lazar, Ronald M.,
Gerstein, Hertzel C.,
Murray, Anne M.,
Sullivan, Mark D.,
Horowitz, Karen R.,
Ding, Jingzhong,
Marcovina, Santica,
Lovato, Laura,
Lovato, James,
Margolis, Karen L.,
Davatzikos, Christos,
Barzilay, Joshua,
Ginsberg, Henry N.,
Linz, Peter E.,
Miller, Michael E.
Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]
Cognitive rehabilitation changes memory-related brain activity in people with Alzheimer disease
van Paasschen, J.,
Clare, L.,
Yuen, K. S. L.,
Woods, R. T.,
Evans, S. J.,
Parkinson, C. H.,
Rugg, M. D.,
Linden, D. E. J.
Background: People with Alzheimer disease (AD) are capable of new learning when cognitive support is provided, suggesting that there is plasticity even in a degenerating brain. However, it is unclear how a cognition-focused intervention operates on a neural level.; Objective: The present study examined the effects of cognitive rehabilitation (CR) on memory-related brain activation in […]
Magnetization transfer imaging in premanifest and manifest huntington disease: a 2-year follow-up
van den Bogaard, S. J. A.,
Dumas, E. M.,
Hart, E. P.,
Milles, J.,
Reilmann, R.,
Stout, J. C.,
Craufurd, D.,
Gibbard, C. R.,
Tabrizi, S. J.,
van Buchem, M. A.,
van der Grond, J.,
Roos, R. A. C.
Background and Purpose: MTI is a quantitative MR imaging technique that has recently demonstrated structural integrity differences between controls and patients with HD. Potentially, MTI can be used as a biomarker for monitoring disease progression. To establish the value of MTI as a biomarker, we aimed to examine the change in these measures during the […]
Neuroimaging predictors of brain amyloidosis in mild cognitive impairment
Objective: To identify a neuroimaging signature predictive of brain amyloidosis as a screening tool to identify individuals with mild cognitive impairment (MCI) that are most likely to have high levels of brain amyloidosis or to be amyloid-free.; Methods: The prediction model cohort included 62 MCI subjects screened with structural magnetic resonance imaging (MRI) and (11) […]
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients
Tikka, S.,
Mykkanen, K.,
Ruchoux, M.-M.,
Bergholm, R.,
Junna, M.,
Poyhonen, M.,
Yki-Jarvinen, H.,
Joutel, A.,
Viitanen, M.,
Baumann, M.,
Kalimo, H.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary subcortical vascular dementia. It is caused by mutations in NOTCH3 gene, which encodes a large transmembrane receptor Notch3. The key pathological finding is the accumulation of granular osmiophilic material (GOM), which contains extracellular domains of Notch3, on degenerating vascular smooth […]
MRI sequence findings in sporadic Creutzfeldt-Jakob disease
MRI has had an important role in the diagnosis of Creutzfeldt-Jakob disease (CJD). The aim of our study was to compare the efficacy of different MRI sequences among six biopsy-proven patients with sporadic CJD (sCJD) and seven patients with probable sCJD. These 13 patients with CJD aged from 36 years to 75 years (mean age: […]
Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study
Teipel, Stefan J.,
Reuter, Sigrid,
Stieltjes, Bram,
Acosta-Cabronero, Julio,
Ernemann, Ulrike,
Fellgiebel, Andreas,
Filippi, Massimo,
Frisoni, Giovanni,
Hentschel, Frank,
Jessen, Frank,
Klöppel, Stefan,
Meindl, Thomas,
Pouwels, Petra J.W.,
Hauenstein, Karl-Heinz,
Hampel, Harald
Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans […]