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Comparing registration methods for mapping brain change using tensor-based morphometry

Authors

Yanovsky, Igor, Leow, Alex D., Lee, Suh, Osher, Stanley J., Thompson, Paul M.

Journal

Medical Image Analysis, Volume: 13, No.: 5, Pages.: 679-700

Year of Publication

2009

Abstract

Measures of brain changes can be computed from sequential MRI scans, providing valuable information on disease progression for neuroscientific studies and clinical trials. Tensor-based morphometry (TBM) creates maps of these brain changes, visualizing the 3D profile and rates of tissue growth or atrophy. In this paper, we examine the power of different nonrigid registration models to detect changes in TBM, and their stability when no real changes are present. Specifically, we investigate an asymmetric version of a recently proposed Unbiased registration method, using mutual information as the matching criterion. We compare matching functionals (sum of squared differences and mutual information), as well as large-deformation registration schemes (viscous fluid and inverse-consistent linear elastic registration methods versus Symmetric and Asymmetric Unbiased registration) for detecting changes in serial MRI scans of 10 elderly normal subjects and 10 patients with Alzheimer’s Disease scanned at 2-week and 1-year intervals. We also analyzed registration results when matching images corrupted with artificial noise. We demonstrated that the unbiased methods, both symmetric and asymmetric, have higher reproducibility. The unbiased methods were also less likely to detect changes in the absence of any real physiological change. Moreover, they measured biological deformations more accurately by penalizing bias in the corresponding statistical maps.;

Bibtex Citation

@article{Yanovsky_2009, doi = {10.1016/j.media.2009.06.002}, url = {http://dx.doi.org/10.1016/j.media.2009.06.002}, year = 2009, month = {oct}, publisher = {Elsevier {BV}}, volume = {13}, number = {5}, pages = {679--700}, author = {Igor Yanovsky and Alex D. Leow and Suh Lee and Stanley J. Osher and Paul M. Thompson}, title = {Comparing registration methods for mapping brain change using tensor-based morphometry}, journal = {Medical Image Analysis} }

Keywords

aged, aged, 80 and over, algorithms, alzheimer disease, brain, diffusion magnetic resonance imaging, female, humans, image enhancement, male, methods, middle aged, pathology, pattern recognition automated, reproducibility of results, sensitivity and specificity, subtraction technique

Countries of Study

USA

Types of Dementia

Alzheimer’s Disease

Types of Study

Cohort Study

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Neuroimaging (e.g. MRI, PET, CAT etc.)