This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Cognitive rehabilitation changes memory-related brain activity in people with Alzheimer disease


van Paasschen, J., Clare, L., Yuen, K. S. L., Woods, R. T., Evans, S. J., Parkinson, C. H., Rugg, M. D., Linden, D. E. J.


Neurorehabilitation And Neural Repair, Volume: 27, No.: 5, Pages.: 448-459

Year of Publication



Background: People with Alzheimer disease (AD) are capable of new learning when cognitive support is provided, suggesting that there is plasticity even in a degenerating brain. However, it is unclear how a cognition-focused intervention operates on a neural level.; Objective: The present study examined the effects of cognitive rehabilitation (CR) on memory-related brain activation in people with early-stage AD, as measured by functional magnetic resonance imaging (fMRI).; Methods: A total of 19 participants either received 8 weeks of CR treatment (n = 7) or formed a control group (n = 12). We scanned participants pretreatment and posttreatment while they learned and recognized unfamiliar face-name pairs.; Results: Following treatment, the CR group showed higher brain activation during recognition of face-name pairs in the left middle and inferior frontal gyri, the left insula, and 2s regions in the right medial parietal cortex. The control group showed decreased activation in these areas during recognition after the intervention period. Neither group showed an activation change during encoding. Behavioral performance on face-name learning did not improve for either group.; Conclusions: We suggest that CR may have operated on the process of recognition through partial restoration of function in frontal brain areas that are less compromised in early-stage AD and that physiological markers may be more sensitive indicators of brain plasticity than behavioral performance.;

Bibtex Citation

@article{van_Paasschen_2013, doi = {10.1177/1545968312471902}, url = {}, year = 2013, month = {jan}, publisher = {{SAGE} Publications}, volume = {27}, number = {5}, pages = {448--459}, author = {J. van Paasschen and L. Clare and K. S. L. Yuen and R. T. Woods and S. J. Evans and C. H. Parkinson and M. D. Rugg and D. E. J. Linden}, title = {Cognitive Rehabilitation Changes Memory-Related Brain Activity in People With Alzheimer Disease}, journal = {Neurorehabilitation and Neural Repair} }


aged, aged, 80 and over, alzheimer disease, analysis of variance, association learning, associative memory, blood supply, brain, cognitive therapy, cognitive treatment, complications, etiology, facename learning, female, fmri, humans, magnetic resonance imaging, male, memory disorders, mental status schedule, middle aged, multivariate analysis, neuroimaging, outcome assessment (health care), oxygen, pathology, pattern recognition visual, photic stimulation, rehabilitation, relaxation therapy, time factors

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Non randomised controlled trial

Type of Outcomes


Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Adult safeguarding and abuse detection/prevention