This database contains 114 studies, archived under the term: "mild cognitive impairment"
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The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults
Barnes, Deborah E.,
Santos-Modesitt, Wendy,
Poelke, Gina,
Kramer, Arthur F.,
Castro, Cynthia,
Middleton, Laura E.,
Yaffe, Kristine
Importance: The prevalence of cognitive impairment and dementia are projected to rise dramatically during the next 40 years, and strategies for maintaining cognitive function with age are critically needed. Physical or mental activity alone result in relatively small, domain-specific improvements in cognitive function in older adults; combined interventions may have more global effects.; Objective: To […]
Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial
Cyarto, Elizabeth V.,
Lautenschlager, Nicola T.,
Desmond, Patricia M.,
Ames, David,
Szoeke, Cassandra,
Salvado, Olivier,
Sharman, Matthew J.,
Ellis, Kathryn A.,
Phal, Pramit M.,
Masters, Colin L.,
Rowe, Christopher C.,
Martins, Ralph N.,
Cox, Kay L.
Background: Older adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are considered at increased risk of cognitive decline. Vascular risk factors (VRF), including hypertension, heart disease, smoking, hypercholesterolemia and lack of physical activity (PA) have been identified as modifiable risk factors contributing to cognitive decline, and white matter […]
Acute caffeine administration effect on brain activation patterns in mild cognitive impairment
Haller, Sven,
Montandon, Marie-Louise,
Rodriguez, Cristelle,
Moser, Dominik,
Toma, Simona,
Hofmeister, Jeremy,
Sinanaj, Indrit,
Lovblad, Karl-Olof,
Giannakopoulos, Panteleimon
Previous studies showed that acute caffeine administration enhances task-related brain activation in elderly individuals with preserved cognition. To explore the effects of this widely used agent on cognition and brain activation in early phases of cognitive decline, we performed a double-blinded, placebo-controlled functional magnetic resonance imaging (fMRI) study during an n-back working memory task in […]
Ceraxon (citicoline) in the treatment of the mild cognitive impairment syndrome
The objective was to study efficacy and safety of ceraxon (citicoline) used perorally in dose 1000 mg daily in the treatment of cognitive disturbances in patients with amnesic type of mild cognitive impairment (MCI). Twenty patients, aged from 50 to 90 years, received ceraxon in dose 1000 mg twice a day during 90 days. The […]
Influence of lithium treatment on GDNF serum and CSF concentrations in patients with early Alzheimer’s disease
Straten, Guido,
Saur, Ralf,
Laske, Christoph,
Gasser, Thomas,
Annas, Peter,
Basun, Hans,
Leyhe, Thomas
Preclinical and clinical studies gave evidence that lithium could be useful in the treatment of Alzheimer’s disease (AD). One possible mechanism of action might be the induction of neurotrophins. Recently, we found a significant increase of brain-derived neurotrophic factor (BDNF) serum levels in AD patients treated with lithium and a significant decrease of ADAS Cog […]
An MRI substudy of a donepezil clinical trial in mild cognitive impairment
Schuff, Norbert,
Suhy, Joyce,
Goldman, Robert,
Xu, Yikang,
Sun, Yijun,
Truran-Sacrey, Diana,
Murthy, Anita
A magnetic resonance imaging (MRI) study was conducted as part of an intervention study in subjects with amnestic mild cognitive impairment (aMCI) to assess donepezil’s treatment effect on brain atrophy. Adults with aMCI were randomly assigned to double-blind treatment with 10 mg/day donepezil hydrochloride or placebo for 48 weeks. Brain MRI scans were acquired at […]
Cognitive training changes hippocampal function in mild cognitive impairment: a pilot study
A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved […]
Effects of a 6-month cognitive intervention on brain metabolism in patients with amnestic MCI and mild Alzheimer’s disease
Förster, Stefan,
Buschert, Verena C.,
Teipel, Stefan J.,
Friese, Uwe,
Buchholz, Hans-Georg,
Drzezga, Alexander,
Hampel, Harald,
Bartenstein, Peter,
Buerger, Katharina
The effect of cognitive intervention on brain metabolism in AD is largely unexplored. Therefore, we aimed to investigate cognitive parameters and 18FDG PET to test for effects of a cognitive intervention in patients with aMCI or mild AD. Patients with aMCI (N = 24) or mild AD (N = 15) were randomly assigned either to […]