This database contains 542 studies, archived under the term: "middle aged"
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Effects of a psychological intervention in a primary health care center for caregivers of dependent relatives: a randomized trial
Rodriguez-Sanchez, E.,
Patino-Alonso, M. C.,
Mora-Simon, S.,
Gomez-Marcos, M. A.,
Perez-Penaranda, A.,
Losada-Baltar, A.,
Garcia-Ortiz, L.
Purpose: To assess, in the context of Primary Health Care (PHC), the effect of a psychological intervention in mental health among caregivers (CGs) of dependent relatives.; Design and Methods: Randomized multicenter, controlled clinical trial. The 125 CGs included in the trial were receiving health care in PHC.; Inclusion Criteria: Identifying oneself as principal CG of […]
Cognitive change in donepezil treated patients with vascular or mixed dementia
Rockwood, Kenneth,
Mitnitski, Arnold,
Black, Sandra E.,
Richard, Matthew,
Defoy, Isabelle,
Vaspect study investigators
Background: vascular dementia (VaD) and mixed Alzheimer’s disease (AD/VaD) are common. How best to monitor treatment is not clear. Our objective was to compare responsiveness and construct validity of change scores, following donepezil treatment, of the standardized Mini-Mental State Examination (sMMSE) and other measures potentially usable in primary care.; Methods: A six-month, outcome measurement study. […]
Prospective flutemetamol positron emission tomography and histopathology in normal pressure hydrocephalus
Rinne, Juha O.,
Frantzen, Janek,
Leinonen, Ville,
Lonnrot, Kimmo,
Laakso, Aki,
Virtanen, Kirsi A.,
Solin, Olof,
Kotkansalo, Anna,
Koivisto, Anne,
Sajanti, Juha,
Karppinen, Atte,
Lehto, Hanna,
Rummukainen, Jaana,
Buckley, Chris,
Smith, Adrian,
Jones, Paul A.,
Sherwin, Paul,
Farrar, Gill,
McLain, Richard,
Kailajarvi, Marita,
Grachev, Igor D.
Unlabelled: BACKGOUND/OBJECTIVE: To determine the level of association between uptake of the amyloid positron emission tomography (PET) imaging agent [(18)F]flutemetamol and the level of amyloid-β measured by immunohistochemical and histochemical staining in a frontal cortical region biopsy site.; Methods: Seventeen patients with probable normal pressure hydrocephalus (NPH) underwent prospective [(18)F]flutemetamol PET and subsequent frontal cortical […]
Vital conversations with family in the nursing home: preparation for end-stage dementia care
Family members of persons with advanced dementia may be asked to make complex treatment decisions without having adequate knowledge regarding the risks and benefits. This 6-month, prospective, randomized trial tested the effect of an intervention consisting of a face-to-face, structured conversation about end-of-life care options with family members of nursing home residents with advanced dementia. […]
Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors
Reijmer, Yael D.,
van den Berg, Esther,
de Bresser, Jeroen,
Kessels, Roy P. C.,
Kappelle, L. Jaap,
Algra, Ale,
Biessels, Geert Jan
Background: Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. We examined brain imaging correlates and vascular and metabolic risk factors of accelerated cognitive decline in patients with type 2 diabetes.; Methods: Cognitive functioning and brain volume as well as metabolic and vascular risk factors were assessed twice in […]
Insulin resistance and medial prefrontal gyrus metabolism in women receiving hormone therapy
Rasgon, Natalie L.,
Kenna, Heather A.,
Wroolie, Tonita E.,
Williams, Katherine E.,
DeMuth, Bevin N.,
Silverman, Daniel H. S.
Insulin resistance (IR) is a putative risk factor for cognitive decline and dementia, and has been shown to impede neuronal glucose metabolism in animal models. This post hoc study focused on metabolic changes in the medial prefrontal region, a brain region exhibiting decline years before documented cognitive changes, relative to high or low IR status […]
Platelet decline as a predictor of brain injury in HIV infection
Ragin, Ann B.,
D’Souza, Gypsyamber,
Reynolds, Sandra,
Miller, Eric,
Sacktor, Ned,
Selnes, Ola A.,
Martin, Eileen,
Visscher, Barbara R.,
Becker, James T.
An association between platelet decline and increased risk of progression to dementia has been observed in an advanced HIV infection cohort study. This investigation evaluated the prognostic significance of platelet decline for dementia, for psychomotor slowing, and for brain injury, as quantified in vivo, in a much larger population of HIV+ men. Platelet counts and […]
The ALS-FTD-Q: a new screening tool for behavioral disturbances in ALS
Raaphorst, Joost,
Beeldman, Emma,
Schmand, Ben,
Berkhout, Joris,
Linssen, Wim H. J. P.,
van den Berg, Leonard H.,
Pijnenburg, Yolande A.,
Grupstra, Hepke F.,
Weikamp, Janneke G.,
Schelhaas, H. Jurgen,
Papma, Janne M.,
van Swieten, John C.,
de Visser, Marianne,
de Haan, Rob J.
Objective: The assessment of behavioral disturbances in amyotrophic lateral sclerosis (ALS) is important because of the overlap with the behavioral variant of frontotemporal dementia (ALS-bvFTD). Motor symptoms and dysarthria are not taken into account in currently used behavioral questionnaires. We examined the clinimetric properties of a new behavioral questionnaire for patients with ALS (Amyotrophic Lateral […]
Task-specific training in Huntington disease: a randomized controlled feasibility trial
Quinn, L.,
Debono, K.,
Dawes, H.,
Rosser, A. E.,
Nemeth, A. H.,
Rickards, H.,
Tabrizi, S. J.,
Quarrell, O.,
Trender-Gerhard, I.,
Kelson, M. J.,
Townson, J.,
Busse, M.
Background: Task-specific training may be a suitable intervention to address mobility limitations in people with Huntington disease (HD).; Objective: The aim of this study was to assess the feasibility and safety of goal-directed, task-specific mobility training for individuals with mid-stage HD.; Design: This study was a randomized, blinded, feasibility trial; participants were randomly assigned to […]