This database contains 542 studies, archived under the term: "middle aged"
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Detecting frontotemporal dysfunction in ALS: utility of the ALS Cognitive Behavioral Screen (ALS-CBS)
Woolley, Susan C.,
York, Michele K.,
Moore, Dan H.,
Strutt, Adriana M.,
Murphy, Jennifer,
Schulz, Paul E.,
Katz, Jonathan S.
Up to half of patients with ALS develop cognitive impairment during the course of the illness. Despite this, there is no simple tool for screening patients in the clinical setting. This study examines the sensitivity, specificity and accuracy of the ALS Cognitive Behavioral Screen (ALS-CBS). We administered the measure to 112 ALS patients, including 31 […]
The influence of Nintendo-Wii® bowling upon residents of retirement homes
The few studies dealing with the positive effects of health and well-being of older people are only one-sided. The aim of the study therefore was to analyze the effects of Nintendo-Wii® bowling on daily function, state of dementia, quality of life, cognition and motor skills in retirement home inhabitants. The study was performed with 27 […]
Cognitive function in elderly marathon runners: cross-sectional data from the marathon trial (APSOEM)
Winker, Robert,
Lukas, Ina,
Perkmann, Thomas,
Haslacher, Helmut,
Ponocny, Elisabeth,
Lehrner, Johann,
Tscholakoff, Dimiter,
Dal-Bianco, Peter
Background: Cognitive impairment of the elderly contributes to morbidity, loss of quality of life, and impairment of work ability in aging western societies. Thus strategies to maintain cognitive function at an advanced age imply a great challenge to Occupational Medicine.; Aim: To study whether intensive endurance exercise training is associated with better cognitive performance and […]
Walking stabilizes cognitive functioning in Alzheimer’s disease (AD) across one year
Winchester, J.,
Dick, M.B.,
Gillen, D.,
Reed, B.,
Miller, B.,
Tinklenberg, J.,
Mungas, D.,
Chui, H.,
Galasko, D.,
Hewett, L.,
Cotman, C.W.
AD is a public health epidemic, which seriously impacts cognition, mood and daily activities; however, one type of activity, exercise, has been shown to alter these states. Accordingly, we sought to investigate the relationship between exercise and mood, in early-stage AD patients (N=104) from California, over a 1-year period. Patients completed the Mini-Mental State Examination […]
Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial
Williamson, Jeff D.,
Launer, Lenore J.,
Bryan, R. Nick,
Coker, Laura H.,
Lazar, Ronald M.,
Gerstein, Hertzel C.,
Murray, Anne M.,
Sullivan, Mark D.,
Horowitz, Karen R.,
Ding, Jingzhong,
Marcovina, Santica,
Lovato, Laura,
Lovato, James,
Margolis, Karen L.,
Davatzikos, Christos,
Barzilay, Joshua,
Ginsberg, Henry N.,
Linz, Peter E.,
Miller, Michael E.
Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]
Video-based coping skills to reduce health risk and improve psychological and physical well-being in Alzheimer’s disease family caregivers
Williams, Virginia P.,
Bishop-Fitzpatrick, Lauren,
Lane, James D.,
Gwyther, Lisa P.,
Ballard, Edna L.,
Vendittelli, Analise P.,
Hutchins, Tiffany C.,
Williams, Redford B.
Objective: To determine whether video-based coping skills (VCS) training with telephone coaching reduces psychosocial and biological markers of distress in primary caregivers of a relative with Alzheimer’s disease or related dementia (ADRD).; Methods: A controlled clinical trial was conducted with 116 ADRD caregivers who were assigned, alternately as they qualified for the study, to a […]
Tailored educational intervention for primary care to improve the management of dementia: the EVIDEM-ED cluster randomized controlled trial
Wilcock, Jane,
Iliffe, Steve,
Griffin, Mark,
Jain, Priya,
Thuné-Boyle, Ingela,
Lefford, Frances,
Rapp, David
Background: Early diagnosis of dementia is important because this allows those with dementia and their families to engage support and plan ahead. However, dementia remains underdetected and suboptimally managed in general practice. Our objective was to test the effect of a workplace-based tailored educational intervention developed for general practice on the clinical management of people […]
Mindfulness-based stress reduction for family caregivers: a randomized controlled trial
Whitebird, R. R.,
Kreitzer, M.,
Crain, A. L.,
Lewis, B. A.,
Hanson, L. R.,
Enstad, C. J.
Purpose: Caring for a family member with dementia is associated with chronic stress, which can have significant deleterious effects on caregivers. The purpose of the Balance Study was to compare a mindfulness-based stress reduction (MBSR) intervention to a community caregiver education and support (CCES) intervention for family caregivers of people with dementia.; Design and Methods: […]
The northwestern anagram test: measuring sentence production in primary progressive aphasia
Weintraub, S.,
Mesulam, M.-M.,
Wieneke, C.,
Rademaker, A.,
Rogalski, E. J.,
Thompson, C. K.
Primary progressive aphasia (PPA) is a clinical dementia syndrome with early symptoms of language dysfunction. Postmortem findings are varied and include Alzheimer disease and frontotemporal lobar degeneration (FTLD), both tauopathies and TAR DNA binding protein (TDP-43) proteinopathies. Clinical-pathological correlations in PPA are complex but the presence in the clinical profile of agrammatism has a high […]