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The northwestern anagram test: measuring sentence production in primary progressive aphasia


Weintraub, S., Mesulam, M.-M., Wieneke, C., Rademaker, A., Rogalski, E. J., Thompson, C. K.


American Journal Of Alzheimer's Disease And Other Dementias, Volume: 24, No.: 5, Pages.: 408-416

Year of Publication



Primary progressive aphasia (PPA) is a clinical dementia syndrome with early symptoms of language dysfunction. Postmortem findings are varied and include Alzheimer disease and frontotemporal lobar degeneration (FTLD), both tauopathies and TAR DNA binding protein (TDP-43) proteinopathies. Clinical-pathological correlations in PPA are complex but the presence in the clinical profile of agrammatism has a high association with tauopathy. Grammatical competence is difficult to assess in the clinical setting with available methods. This article describes the Northwestern Anagram Test (NAT), a new clinical measure of sentence production. A total of 16 patients with PPA and their controls assembled single printed words to create sentences describing pictures. Northwestern Anagram Test performance was significantly correlated with a measure of sentence production and with aphasia severity but not with measures of naming, single word comprehension, object recognition, or motor speech. The NAT can be used to assess syntax competence when patients cannot be tested with measures that require intact speech production.;

Bibtex Citation

@article{Weintraub_2009, doi = {10.1177/1533317509343104}, url = {}, year = 2009, month = {aug}, publisher = {{SAGE} Publications}, volume = {24}, number = {5}, pages = {408--416}, author = {S. Weintraub and M.-M. Mesulam and C. Wieneke and A. Rademaker and E. J. Rogalski and C. K. Thompson}, title = {The Northwestern Anagram Test: Measuring Sentence Production in Primary Progressive Aphasia}, journal = {American Journal of Alzheimer{textquotesingle}s Disease and Other Dementias} }


aged, aphasia broca, aphasia primary progressive, diagnosis, female, humans, male, middle aged, neuropsychological tests, reading, reproducibility of results, speech disorders, standards, vocabulary

Countries of Study


Types of Dementia

Dementia (general / unspecified), Mild Cognitive Impairment (MCI)

Types of Study

Non randomised controlled trial

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Cognition testing (inc. task driven tests such as clock drawing)