Ford, A. H., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., Almeida, O. P.

[Correction Notice: An erratum for this article was reported in Vol 77(8) of Neurology (see record [rid]2011-21984-022[/rid]). In the original article, the daily dose of vitamin B12 used in the trial was reported as 400 μg, but it should have been 500 μg.] Objective: To investigate whether supplementing older men with vitamins B12, B6, and […]

Schiepers, Olga J. G., van Boxtel, Martin P. J., de Groot, Renate H. M., Jolles, Jelle, Kok, Frans J., Verhoef, Petra, Durga, Jane

Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are important for normal functioning of the brain. Although aberrant DNA methylation has been implicated in neurodevelopmental disorders, the relationship between DNA methylation status […]

Dodge, Hiroko H., Katsumata, Yuriko, Todoriki, Hidemi, Yasura, Shoutoku, Willcox, D. Craig, Bowman, Gene L., Willcox, Bradley, Leonard, Scott, Clemons, Aaron, Oken, Barry S., Kaye, Jeffrey A., Traber, Maret G.

Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as […]

Morillas-Ruiz, J. M., Rubio-Perez, J. M., Albaladejo, M. D., Zafrilla, P., Parra, S., Vidal-Guevara, M. L.

Background: A large body of evidence supports a role of oxidative stress in Alzheimer disease (AD) and in cerebrovascular disease. Blood levels of homocysteine may be increased in AD and hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct neurotoxic mechanisms. Even in the absence of vitamin deficiency, plasma total homocysteine (tHcy) concentration may […]

Kwok, T., Lee, J., Law, C. B., Pan, P. C., Yung, C. Y., Choi, K. C., Lam, L. C.

Introduction: Whether homocysteine lowering by B vitamins can reduce cognitive decline in Alzheimer disease and vascular dementia patients is unclear.; Methods and Materials: 140 subjects with mild to moderate Alzheimer disease or vascular dementia were randomly assigned to take 1 mg of methylcobalamin and 5 mg of folic acid, or placebo once daily for 24 […]

Richard, Edo, Kuiper, Roy, Dijkgraaf, Marcel G. W., van Gool, Willem A.

Objectives: To investigate whether vascular care slows dementia progression in patients with Alzheimer’s disease with cerebrovascular lesions on neuroimaging.; Design: Multicenter randomized controlled clinical trial with 2-year follow-up.; Setting: Neurological and geriatric outpatient clinics in 10 Dutch hospitals: three academic, five teaching, and two midsize community hospitals.; Participants: One hundred thirty community-dwelling patients with mild […]

Ford, A. H., Flicker, L., Alfonso, H., Thomas, J., Clarnette, R., Martins, R., Almeida, O. P.

Objective: To investigate whether supplementing older men with vitamins B(12), B(6), and folic acid improves cognitive function.; Methods: The investigators recruited 299 community-representative hypertensive men 75 years and older to a randomized, double-blind controlled clinical trial of folic acid, vitamin B(6), and B(12) supplementation vs placebo over 2 years. The primary outcome of interest was […]

de Waal, Hanneke, Stam, Cornelis J., Lansbergen, Marieke M., Wieggers, Rico L., Kamphuis, Patrick J. G. H., Scheltens, Philip, Maestú, Fernando, van Straaten, Elisabeth C. W.

Background: Synaptic loss is a major hallmark of Alzheimer’s disease (AD). Disturbed organisation of large-scale functional brain networks in AD might reflect synaptic loss and disrupted neuronal communication. The medical food Souvenaid, containing the specific nutrient combination Fortasyn Connect, is designed to enhance synapse formation and function and has been shown to improve memory performance […]