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Comparisons of plasma/serum micronutrients between Okinawan and Oregonian elders: a pilot study


Dodge, Hiroko H., Katsumata, Yuriko, Todoriki, Hidemi, Yasura, Shoutoku, Willcox, D. Craig, Bowman, Gene L., Willcox, Bradley, Leonard, Scott, Clemons, Aaron, Oken, Barry S., Kaye, Jeffrey A., Traber, Maret G.


The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences, Volume: 65, No.: 10, Pages.: 1060-1067

Year of Publication



Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as the Oregon sample, from the Keys to Optimal Cognitive Aging Project. All participants were aged 85 years and older without cognitive impairment. We found that the Okinawan elders used fewer vitamin supplements but had similar levels of vitamin B(12) and α-tocopherol, lower folate and γ-tocopherol, compared with Oregonian elders. That is, we did not find a uniform pattern of circulating micronutrients, suggesting that micronutrients other than those examined here or other lifestyle factors than nutrition could play an important role in achieving successful cognitive aging.;

Bibtex Citation

@article{Dodge_2010, doi = {10.1093/gerona/glq124}, url = {}, year = 2010, month = {jul}, publisher = {Oxford University Press ({OUP})}, volume = {65A}, number = {10}, pages = {1060--1067}, author = {H. H. Dodge and Y. Katsumata and H. Todoriki and S. Yasura and D. C. Willcox and G. L. Bowman and B. Willcox and S. Leonard and A. Clemons and B. S. Oken and J. A. Kaye and M. G. Traber}, title = {Comparisons of Plasma/Serum Micronutrients Between Okinawan and Oregonian Elders: A Pilot Study}, journal = {The Journals of Gerontology Series A: Biological Sciences and Medical Sciences} }


aged, 80 and over, blood, cognition, female, folic acid, homocysteine, humans, japan, male, micronutrients, oregon, physiology, pilot projects, potassium, sodium, vitamin b 12

Countries of Study

Japan, USA

Types of Study

Cohort Study

Type of Interventions

Risk Factor Modification

Risk Factor Modifications

General population health promotion