This database contains 219 studies, archived under the term: "complications"
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Rivastigmine for mild cognitive impairment in Parkinson disease: a placebo-controlled study
Mild cognitive impairment (MCI) in Parkinson’s disease (PD) may be associated with subtle functional impairment and worse quality of life. The objective of this study was to determine the efficacy and tolerability of rivastigmine for PD-MCI. Patients with PD-MCI (n = 28) were enrolled in a 24-week, randomized, double-blind, placebo-controlled, crossover, single-site study of the rivastigmine transdermal […]
Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial
Cummings, J. L.,
Lyketsos, C. G.,
Peskind, E. R.,
Porsteinsson, A. P.,
Mintzer, J. E.,
Scharre, D. W.,
De La Gandara, J. E.,
Agronin, M.,
Davis, C. S.,
Nguyen, U.,
Shin, P.,
Tariot, P. N.,
Siffert, J.
IMPORTANCE: Agitation is common among patients with Alzheimer disease; safe, effective treatments are lacking. OBJECTIVE: To assess the efficacy, safety, and tolerability of dextromethorphan hydrobromide-quinidine sulfate for Alzheimer disease-related agitation. DESIGN, SETTING, AND PARTICIPANTS: Phase 2 randomized, multicenter, double-blind, placebo-controlled trial using a sequential parallel comparison design with 2 consecutive 5-week treatment stages conducted August […]
Effects of telmisartan on the level of Aβ1-42, interleukin-1β, tumor necrosis factor α and cognition in hypertensive patients with Alzheimer’s disease
Li, Wei,
Zhang, Jie-Wen,
Lu, Fen,
Ma, Ming-Ming,
Wang, Jiang-qiao,
Suo, Ai-Qin,
Bai, Ying-ying,
Liu, Hui-qin
Objective: To explore the effects of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor γ-stimulating activity, on the levels of Aβ1-42, interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) and cognition in elderly hypertensive patients with Alzheimer’s disease (AD).; Methods: A total of 48 patients with probable AD and essential hypertension were randomly […]
Screening cognition in the elderly with metabolic syndrome
Viscogliosi, Giovanni,
Andreozzi, Paola,
Chiriac, Iulia Maria,
Cipriani, Elisa,
Servello, Adriana,
Ettorre, Evaristo,
Marigliano, Vincenzo
Background: Metabolic syndrome reaches its highest prevalence in the elderly, and evidence suggests that metabolic syndrome could be an independent risk factor for cognitive impairment. The aims of this study were to detect whether patients with metabolic syndrome have lower cognition and to investigate whether there is a relationship with cognition and single metabolic syndrome […]
Cognitive behavioural therapy (CBT) for anxiety in people with dementia: study protocol for a randomised controlled trial
Spector, Aimee,
Orrell, Martin,
Lattimer, Miles,
Hoe, Juanita,
King, Michael,
Harwood, Kate,
Qazi, Afifa,
Charlesworth, Georgina
Background: Many people with dementia experience anxiety, which can lead to decreased independence, relationship difficulties and increased admittance to care homes. Anxiety is often treated with antipsychotic medication, which has limited efficacy and serious side effects. Cognitive behavioural therapy (CBT) is widely used to treat anxiety in a range of populations, yet no RCTs on […]
A new frontier in spaced retrieval memory training for persons with Alzheimer’s disease
The objective of this pilot study was to investigate how a memory training technique called “Spaced Retrieval” (SR) might be effectively applied in helping persons with Alzheimer’s disease improve their recall of recent events. Capitalising on the interdependence among spared and impaired memory systems, it was hypothesised that SR training with support at encoding and […]
Alzheimer’s disease: is pacemaker implantation safe?
Osmonov, Damirbek,
Ozcan, Kazim Serhan,
Altay, Servet,
Erdinler, Izzet,
Yildirim, Ersin,
Türkkan, Ceyhan,
Canga, Yigit,
Alper, Ahmet Taha,
Cakmak, Nazmiye,
Gürkan, Kadir
Aim: To evaluate the safety of pacemaker implantation in patients with Alzheimer’s disease (AD).; Methods: We reviewed all cases admitted to our institution between January 2008 and June 2009, with symptomatic bradyarrhythmia for whom a permanent pacemaker was implanted. Beginning in June 2009, we prospectively collected data from all patients with the same diagnosis and […]