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From Alzheimer’s disease retrogenesis: a new care strategy for patients with advanced dementia


Venturelli, Massimo, Magalini, Alessandra, Scarsini, Renato, Schena, Federico


American Journal Of Alzheimer's Disease And Other Dementias, Volume: 27, No.: 7, Pages.: 483-489

Year of Publication



There is evidence that exercise may reduce the progressive cognitive dysfunction of Alzheimer’s disease (AD). However, no previous investigation has studiethe acute effects of adapted games (AG) on patients with AD. The aim of this study was to examine the acute effects of AG on the agitated behavior (rating scale Agitated Behavior Rating Scale [ABRS]) and cognitive performance (Test for Severe Impairment [TSI]) of patients with advanced dementia. Twenty patients (83±4 yrs) participated in AG and placebo activities (PL). Agitated behavior and cognitive performance were compared before and after 30 minutes of AG and PL. In the hour after the AG, agitated behavior decreased by ∼4 ABRS points and cognitive performance increased by ∼5 TSI points. On the contrary, after PL we found no change in agitated behavior or cognitive performance. Our data indicate that AG can momentarily reduce agitated behavior and increase the cognitive performance in participants with AD.;

Bibtex Citation

@article{Venturelli_2012, doi = {10.1177/1533317512459794}, url = {}, year = 2012, month = {sep}, publisher = {{SAGE} Publications}, volume = {27}, number = {7}, pages = {483--489}, author = {M. Venturelli and A. Magalini and R. Scarsini and F. Schena}, title = {From Alzheimer{textquotesingle}s Disease Retrogenesis: A New Care Strategy for Patients With Advanced Dementia}, journal = {American Journal of Alzheimer{textquotesingle}s Disease and Other Dementias} }


aged, aged, 80 and over, alzheimer disease, cognition disorders, complications, etiology, exercise therapy, female, humans, male, methods, psychomotor agitation, therapy, treatment outcome

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Non randomised controlled trial

Type of Outcomes

Behaviour, Cognition

Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Exercise (inc. dancing)