This database contains 750 studies, archived under the term: "aged, 80 and over"
Click here to filter this large number of results.
Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial
Objective: Because cholinergic deficits are prominent in dementia with Lewy bodies (DLB), we investigated the effects of a cholinesterase inhibitor, donepezil, in such patients in a randomized, double-blind, placebo-controlled exploratory phase 2 trial.; Methods: One-hundred forty patients with DLB, recruited from 48 specialty centers in Japan, were randomly assigned to receive placebo or 3, 5, […]
STAM protocol in dementia: a multicenter, single-blind, randomized, and controlled trial
Ceccato, Enrico,
Vigato, Giovanna,
Bonetto, Chiara,
Bevilacqua, Albina,
Pizziolo, Paolo,
Crociani, Susanna,
Zanfretta, Emanuele,
Pollini, Lorenza,
Caneva, Paolo Alberto,
Baldin, Lorella,
Frongillo, Cristina,
Signorini, Andrea,
Demoro, Sara,
Barchi, Elisabetta
Background: The Sound Training for Attention and Memory in Dementia (STAM-Dem) is a manualized music-based protocol designed to be used in the rehabilitation of cognitive functions in elderly patients with dementia (PWD).; Method: This was a multicenter, single-blind, randomized, and controlled trial that involved 51 PWD. The objective was to test the STAM-Dem efficacy. Patients […]
Leisure activities alleviate depressive symptoms in nursing home residents with very mild or mild dementia
Objectives: : To examine whether leisure activities can alleviate depressive symptoms among nursing home residents with very mild to mild dementia.; Methods: : A cluster-randomized open-label controlled design. Thirty-six residents with at least moderate depressive symptoms were randomized by home into three conditions-mahjong (a.k.a. mah-jongg), tai chi, and handicrafts (placebo). Activities were conducted three times […]
Concord grape juice supplementation and neurocognitive function in human aging
Krikorian, Robert,
Boespflug, Erin L.,
Fleck, David E.,
Stein, Amanda L.,
Wightman, Jolynne D.,
Shidler, Marcelle D.,
Sadat-Hossieny, Sara
Polyphenol compounds found in berry fruits, in particular flavonoids, have been associated with health benefits including improvement in cognition and neuronal function with aging. Concord grape juice contains polyphenols, including anthocyanins and flavanols, and previous research has shown improvement in a number of human health conditions with grape juice supplementation. In the current study, older […]
The effects of a long-term care walking program on balance, falls and well-being
Background: The effects of a regular and graduated walking program as a stand-alone intervention for individuals in long-term care are unclear. Exercise and fall prevention programs typically studied in long-term care settings tend to involve more than one exercise mode, such as a combination of balance, aerobic, strengthening, and flexibility exercises; and, measures do not […]
Longitudinal changes of fractional anisotropy in Alzheimer’s disease patients treated with galantamine: a 12-month randomized, placebo-controlled, double-blinded study
Likitjaroen, Y.,
Meindl, T.,
Friese, U.,
Wagner, M.,
Buerger, K.,
Hampel, H.,
Teipel, S. J.
Diffusion tensor imaging (DTI) demonstrates decline of fractional anisotropy (FA) as a marker of fiber tract integrity in Alzheimer’s disease (AD). We aimed to assess the longitudinal course of white matter microstructural changes in AD and healthy elderly control (HC) subjects and to evaluate the effects of treatment with the cholinesterase inhibitor galantamine on white […]