This database contains 750 studies, archived under the term: "aged, 80 and over"
Click here to filter this large number of results.
Effectiveness of dementia follow-up care by memory clinics or general practitioners: randomised controlled trial
Meeuwsen, Els J.,
Melis, René J. F.,
Van Der Aa, Geert C. H. M.,
Golüke-Willemse, Gertie A. M.,
De Leest, Benoit J. M.,
Van Raak, Frank H. J. M.,
Schölzel-Dorenbos, Carla J M,
Verheijen, Desiree C. M.,
Verhey, Frans R.J.,
Visser, Marieke C.,
Wolfs, Claire A.,
Adang, Eddy M. M.,
Olde Rikkert, Marcel G. M.
Objective: To examine the effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared with general practitioners.; Design: Multicentre randomised controlled trial.; Setting: Nine memory clinics and 159 general practitioners in the Netherlands.; Participants: 175 patients with a new diagnosis of mild to moderate dementia living in the community and their informal […]
Does a multicomponent exercise program improve dual-task performance in amnestic mild cognitive impairment? A randomized controlled trial
Makizako, Hyuma,
Doi, Takehiko,
Shimada, Hiroyuki,
Yoshida, Daisuke,
Tsutsumimoto, Kota,
Uemura, Kazuki,
Suzuki, Takao
Background and Aims: There has been much interest in exercise interventions as a primary behavioral prevention strategy against cognitive decline. The aim of this study was to evaluate the effect of a multicomponent exercise program on physical and dual-task performances in community-dwelling older adults with amnestic mild cognitive impairment (aMCI).; Methods: Fifty older adults (23 […]
Physical and cognitive stimulation in Alzheimer Disease. the GAIA Project: a pilot study
Maci, Tiziana,
Pira, Francesco Le,
Quattrocchi, Graziella,
Nuovo, Santo Di,
Perciavalle, Vincenzo,
Zappia, Mario
Several data suggest that physical activity and cognitive stimulation have a positive effect on the quality of life (QoL) of people with Alzheimer’s disease (AD), slowing the decline due to the disease. A pilot project was undertaken to assess the effect of cognitive stimulation, physical activity, and socialization on patients with AD and their informal […]
Achetylcholinesterase (AChE) inhibition and serum lipokines in Alzheimer’s disease: friend or foe?
Kovacs, Janos,
Pákáski, Magdolna,
Juhasz, Anna,
Feher, Agnes,
Drótos, Gergely,
Fazekas, Csilla Orsike,
Horvath, Tamas Laszlo,
Janka, Zoltan,
Kálmán, János
Throughout the natural progression of Alzheimer’s disease (AD), the body mass index (BMI) decreases. This is believed to be brought on by the disturbance in the central lipid metabolism, but the exact mechanism is yet unknown. Adipokines (adiponectin, leptin), hormones produced by the adipose tissue, change glucose and lipid metabolism, and have an anorectic effect […]
Evaluation of the regional cerebral blood flow changes during long-term donepezil therapy in patients with Alzheimer’s disease using 3DSRT
Kimura, Noriyuki,
Kumamoto, Toshihide,
Masuda, Teruaki,
Hanaoka, Takuya,
Okazaki, Toshio,
Arakawa, Ryuki
Background: We attempt to evaluate objectively the regional cerebral blood flow (rCBF) changes during long-term donepezil therapy and the relationship between the clinical response and rCBF change in patients with Alzheimer’s disease (AD).; Patients and Methods: Thirty-one patients with mild-to-moderate AD (11 men, 20 female; mean age, 76.2 ± 6.7 years) were treated with donepezil […]
Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study
Kasuya, Masashi,
Meguro, Kenichi,
Okamura, Nobuyuki,
Funaki, Yoshihito,
Ishikawa, Hiroyasu,
Tanaka, Naofumi,
Iwata, Ren,
Yanai, Kazuhiko
The aim of the study was to predict donepezil responders among patients with Alzheimer disease (AD) based on cognitive tests and positron emission tomography. The Mini-Mental State Examination, Digit Symbol subtest (DigSm) of Wechsler Adult Intelligence Scale Revised, and Trail-Making Test A were administered for 80 patients with AD to assess global function, attention, and […]
Predictors of acceptance of offered care management intervention services in a quality improvement trial for dementia
Kaisey, Marwa,
Mittman, Brian,
Pearson, Marjorie,
Connor, Karen I.,
Chodosh, Joshua,
Vassar, Stefanie D.,
Nguyen, France T.,
Vickrey, Barbara G.
Objective: Care management approaches have been proven to improve outcomes for patients with dementia and their family caregivers (dyads). However, acceptance of services in these programs is incomplete, impacting effectiveness. Acceptance may be related to dyad as well as healthcare system characteristics, but knowledge about factors associated with program acceptance is lacking. This study investigates […]